Jose Chianale, Leyna Mulholland, Peter G. Traber, Jorge J. Gumucio – 1 March 1988 – Phenobarbital induces liver cytochrome P‐450 b,e proteins mainly by increasing the rate of transcription of these genes. The mechanism responsible for the phenobarbital increment in the rate of transcription of cytochrome P‐450 b,e genes is unknown. The objective of this study was to assess whether active protein synthesis was needed for phenobarbital to induce the liver cytochrome P‐450 b,e genes.

Stephen P. James – 1 March 1988 – Considerable numbers of large granular lymphocytes (LGL) were isolated from rat liver by a simple method consisting of sinusoidal lavage at elevated (50 cm water column) perfusion pressure. This method gave a yield comparable with the enzymatic dissociation method commonly used for the isolation of nonparenchymal liver cells, but was shorter in time and had the advantage of avoiding the potentially harmful effects of the dissociating enzymes.

1 March 1988 – Men with liver disease are hypogonadal and feminised. European workers consider the liver disease itself to be the major factor but American workers blame alcohol consumption. We studied sexual dysfunction and sex hormones in three matched groups of men; controls (n = 22), those with alcoholic liver disease (n = 21), and those with non‐alcoholic liver disease (n = 21). Men with alcoholic liver disease had more sexual dysfunction.

Marc I. Lorber – 1 March 1988 – Seven patients with hepatitis delta virus (HDV) cirrhosis underwent liver transplantation. In every case the HDV infection was florid but accompanied by an inactive hepatitis B virus (HBV) infection. The patients were given anti‐HB surface antigen (HBsAg) serum globulins and HBV vaccine. Two patients cleared the HBsAg and the HDV, and are alive and well 14 and 15 months, respectively, after transplantation.

Yisrael Isaacson, David H. Van Thiel – 1 March 1988 – The interest in liver transplantation has focused more attention on the mechanisms of injury during hepatic ischemia, preservation, and reperfusion. Although the human liver has been successfully maintained under hypothermic conditions for up to 10 hours, organ preservation remains the major obstacle to liver transplantation.

Robert M. Lowman – 1 March 1988

Kevin D. Mullen, Karen M. Szauter, Arthur J. McCullough, Warren D. Lo, David L. McNeely, Steven R. Ennis, Gary W. Goldstein, A. Lorris Betz, J. Michael Henderson, Michael H. Kutner, W. Dean Warren, Josep Terés, Michael S. Myslobodsky, Gül Baktir, Hans U. Fisch, Georg Karlaganis, Christoph Minder, Johannes Bircher – 1 March 1988

Daphna Fenyves, Gilles Pomier‐Layrargues, Bernard Willems, Jean Cǒté – 1 March 1988 – Previous studies have established the reliability of percutaneous portal venous pressure measurement using a Chiba needle, a procedure requiring fluoroscopic guidance. Intrahepatic pressure has been advocated by some as a simple and safe index of portal venous pressure. The aim of this study was to examine the reliability of intrahepatic pressure measurement and its relationship to portal venous pressure.

Masayoshi Yamauchi, James J. Potter, Esteban Mezey – 1 March 1988 – The hepatic lobular localization of alcohol dehydrogenase was determined in male, female and castrated male rats. Alcohol dehydrogenase immunoreactive protein and activity were increased in female and castrated rats as compared to normal male rats. By immunohistochemistry, alcohol dehydrogenase protein was found localized principally in the perivenous area of the hepatic lobule in all of the animals.

Harry L. Greene, Barbara I. Brown, Daniel T. McClenathan, Rocco M. Agostini, Suzanne R. Taylor – 1 March 1988 – Type IV glycogenosis is due to branching enzyme deficiency and is usually manifested clinically by progressive liver disease with cirrhosis and hepatic failure between the second and fourth years of life. We describe a 5‐year‐old boy who, following an acute febrile illness at 2 years of age, was first noted to have hepatomegaly with mildly elevated serum transaminase levels.