Short‐term effects of propranolol on portal venous pressure

Guadalupe Garcia‐Tsao, Norman D. Grace, Roberto J. Groszmann, Harold O. Conn, Max M. Bermann, Michael J. C. Patrick, Steven S. Morse, Jeanne L. Alberts – 1 January 1986 – The present study was designed to investigate the effect of propranolol on portal pressure of patients with alcoholic cirrhosis and portal hypertension and to correlate these effects with clinical and laboratory parameters. The mean baseline hepatic venous pressure gradient in the 50 patients studied was of 18.2 ± 4.1 mm Hg.

Substrates and products of purified rat liver bilirubin UDP ‐ glucuronosyltransferase

Namita Roy Chowdhury, Irwin M. Arias, Mitchell Lederstein, Jayanta Roy Chowdhury – 1 January 1986 – To determine whether the isoform of UDP‐glucuronosyltransferase which catalyzes the formation of bilirubin monoglucuronide also mediates the formation of bilirubin diglucuronide and other specific sugar conjugates of bilirubin, Wistar rats were treated with clofibrate (300 mg per kg i.p. × 7 days); this resulted in a 200% increase in hepatic transferase specific activity for bilirubin.

A comparative study of the effects of insulin/glucagon infusions, parenteral amino acids and high dose corticosteroids on survival in a rabbit model of acute fulminant hepatitis

Gerald Y. Minuk.M.D., Thomas A. Sherman, Eldon A. Shaffer, Seamus K. Kelly – 1 January 1986 – Acute fulminant hepatitis was induced in 55 healthy adult male rabbits with the potent hepatotoxin galactosamine hydrochloride (3.75 mmoles per kg i.v.). Control rabbits (n = 27) were divided into three groups: Group I (n = 10) underwent sham surgery for placement of an indwelling central venous catheter; Group II (n = 9) received 5% dextrose and water via an indwelling central venous catheter, and Group III (n = 8) received daily intramuscular injections of 0.9% sodium chloride.

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