Late onset hepatic failure: Clinical, serological and histological features

Alexander E. S. Gimson, John O'Grady, Roland J. Ede, Bernard Portmann, Roger Williams – 1 March 1986 – The clinical, laboratory and histological features of 47 patients with what is defined as late onset hepatic failure are reviewed. Twenty‐five of the patients werefemale and 22 male with a median age of 45 years. Hepatic dysfunction was severe as evidenced by the prolongation of prothrombin time (median = 32 sec, range = 17 to 120 sec).

Pyridoxal‐5′‐phosphate and alkaline phosphatase

Lawrence Lumeng – 1 March 1986 – Markedly increased circulating concentrations of pyridoxal‐5′‐phosphate (PLP) were found in each of 14 patients representing all clinical forms of hypophosphatasia, an inborn error characterized by deficient activity of the tissue‐nonspecific (bone/liver/kidney) isoenzyme of alkaline phosphatase (AP). The mean PLP concentration in plasma was 1,174 nM (range, 214 to 3,839 nM) in the patients and 57 ± 26 nM (mean ± S.D.) in 38 control subjects.

Sodium excretion in advanced cirrhosis: Effect of expansion of central blood volume and suppression of plasma aldosterone

Kathleen M. Nicholls, Michael D. Shapiro, Rudiger Kluge, Hsaio‐Min Chung, Daniel G. Bichet, Robert W. Schrier – 1 March 1986 – Sodium excretion in 13 patients with decompensated cirrhosis was measured under baseline conditions of water loading (n = 13) and during conditions designed to improve effective blood volume including: head‐out water immersion alone (n = 13); norepinephrine infusion alone (n = 6), and combined norepinephrine and head‐out water immersion (n = 6).

Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis

Mark L. Bassett, June W. Halliday, Lawrie W. Powell – 1 January 1986 – The role of the measurement of hepatic iron in the diagnosis of genetic hemochromatosis was studied, with particular reference to the differentiation of early hemochromatosis from alcoholic siderosis and the critical hepatic iron concentration associated with fibrosis in hemochromatosis. Hepatic iron was measured in 30 homozygous relatives of 17 hemochromatosis probands, 8 heterozygous relatives, 51 patients with alcoholic liver disease and 40 control subjects.

Transport and intracellular distribution of copper in a human hepatoblastoma cell line, HepG2

Richard J. Stockert, Phyllis S. Grushoff, Anatol G. Morell, Glenn E. Bentley, Harold A. O'Brien, I. Herbert Scheinberg, Irmin Sternlieb – 1 January 1986 – The uptake of radiocopper by HepG2 cells is a saturable, temperature‐dependent and cellular energy‐independent process with a Vmax of 7.1 ± 0.2 pmoles min−1 mg protein−1 andan estimated Km of 3.3 ± 0.5 μM. The rate of copper uptake is reduced at an equimolar concentrationof albumin and is unaffected by zinc at a 10‐fold molar excess.

Isosorbide dinitrate in experimental portal hypertension: A study of factors that modulate the hemodynamic response

Andres T. Blei, Jeanne Gottstein – 1 January 1986 – Isosorbide dinitrate, a long‐acting vasodilator, has been tested in human portal hypertension with conflictingresults. In order to determine some of the factors that could affect the individual response to this drug, we infused isosorbide dinitrate at a low dose (10 to 25 μg per kg per min) and a high dose (100 μg per kg per min) to rats with portal vein stenosis.

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