Hepatotoxicity due to allyl alcohol in deermice depends on alcohol dehydrogenase

Steven A. Belinsky, Blair U. Bradford, Donald T. Forman, Edward B. Glassman, Michael R. Felder, Ronald G. Thurman – 1 November 1985 – The role of alcohol dehydrogenase in the hepatic necrosis due to allyl alcohol was studied in two strains of the deermouse, Peromyscus maniculatus. Mice of the alcohol dehydrogenase‐negative (AdhN) strain which lack alcohol dehydrogenase activity were resistant to allyl alcohol toxicity.

Effects of dietary selenium on hepatic and renal tumorigenesis induced in rats by diethylnitrosamine

Russell D. Dorado, Eduardo A. Porta, Therese M. Aquino – 1 November 1985 – Seven groups of female Sprague‐Dawley rats (˜200 gm initial body weight) were injected i.p. with a single subcarcinogenic dose of diethylnitrosamine (40 mg per kg body weight) between 8 to 10 hr after partial hepatectomy, and after a recovery period of 3 weeks (herein called induction stage) received 0.05% phenobarbital in the diet for the rest of the experiment (promotion stage).

The morphologic spectrum of halothane‐induced hepatic injury: Analysis of 77 cases

Stanley B. Benjamin, Zachary D. Goodman, Kamal G. Ishak, Hyman J. Zimmerman, Nelson S. Irey – 1 November 1985 – Hepatic histopathology and clinical‐pathologic correlations were studied in 77 patients who met clinical criteria for halothane hepatotoxicity. They were divided into groups based on the type of surgery (minor or major) and outcome (nonfatal, biopsy group or fatal, autopsy group).

Hepatocellular carcinoma after thorotrast exposure: Establishment of a new cell line (Mz‐Hep‐1)

Wolfgang G. Dippold, Hans‐Peter Dienes, Alexander Knuth, Walter Sachsse, Winfried Prellwitz, Dieter Bitter‐Suermann, Karl‐Hermann Meyer zum Büschenfelde – 1 November 1985 – A human hepatoma cell line, associated with thorotrast exposure, from an hepatitis B markernegative patient was established as a permanent cell line (Mz‐Hep‐1) in tissue culture. Histology of the primary tumor, as well as phase contrast, transmission and scanning electron microscopy of the cultured cells showed typical characteristics of liver cells.

Electron microscopy of rejected human liver allografts

Robert H. Fennell, John M. Vierling – 1 November 1985 – Recognition by biopsy of liver allograft rejection has been less successful than diagnosis of rejection of cardiac and kidney allografts. In a study of 138 failed liver allografts, we recognized damage to small interlobular bile ducts by lymphocytes as the most useful indicator of the presence of rejection. This is a report of the electron microscopic features of three patients with unequivocal allograft rejection. Lymphocytes and occasional granulocytes penetrated the epithelia of interlobular bile ducts.

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