Marcus A. Rothschild, Murray Oratz, Sidney S. Schreiber – 1 March 1988

Jose Juan Garcia‐Marin, Gloria R. Villanueva, Alejandro Esteller – 1 March 1988 – In one of our earlier studies, an impaired biliary function in diabetes was suggested. We studied bile formation in rats with streptozotocin‐induced diabetes (60 mg per kg body weight). Diabetic rats showed hyperglycemia and hypoinsulinemia, but no significant changes in hematocrit, plasma protein concentration or plasma osmolality. Bile flow was significantly (p < 0.05) reduced (‐23%) as compared with control animals, despite a higher (p < 0.05) bile acid secretion rate (+56%).

Joseph R. Bloomer – 1 March 1988

Gale R. Ramsby – 1 March 1988

Robert A. F. M. Chamuleau, Joris H. N. Creyghton Ineke De Nie, Marinus A. Moerland, Otto R. Van der Lende, Jaap Smidt – 1 March 1988 – During the development of liver fibrosis in rats by an individual dose‐titrated CCl4 administration, hepatic proton spin‐lattice relaxation time (T1) has been measured in vivo every 2 weeks for 8 weeks. Liver content of collagen, triglycerides and water has been measured biochemically in biopsy material.

Robert B. Kirkpatrick, Mitchell D. Green, Lee R. Hagey, Alan F. Hofmann, Thomas R. Tephly – 1 March 1988 – The effect of side chain length on bile acid conjugation by human and rat liver fractions was examined. The rate of conjugation with glucuronic acid, sulfate and coenzyme A of several natural (C24) bile acids was compared with that of their corresponding nor‐bile acids. The rate of coenzyme A ester formation by nor‐bile acids was much lower than that of the natural bile acids.

Michiko Shindo, Tadao Okuno, Masayuki Matsumoto, Makoto Takeda, Tatsuro Takino, Junko Sokawa, Akira Iwata, Yoshihiro Sokawa – 1 March 1988 – We measured 2′,5′‐oligoadenylate synthetase activities in serum and peripheral blood mononuclear cells from 10 patients with chronic hepatitis B who were being treated with interferon so as to determine whether 2′,5′‐oligoadenylate synthetase activity in serum reflected 2′,5′‐oligoadenylate synthetase activity in peripheral blood mononuclear cells, and whether it could be used to monitor interferon treatment.

Glancarlo Spinzi, Vittorio Terruzzi, Giogio Minoli – 1 March 1988 – Percutaneous liver biopsies were performed in 40 adult patients with acute or chronic liver disease. Real‐time sector scan ultrasound of the right upper quadrant was obtained just before biopsy, 1 day after biopsy, and in 10 randomly selected cases 7 days after biopsy. Twenty patients were randomized, by sealed envelope, to 6‐h and 20 patients to 24‐h postbiopsy bed rest. Nine patients (23%) had ultrasound‐detected hematomas 1 day after liver biopsy (7 intrahepatic, 2 subcapsular).

Anna Mae Diehl, Marco Chacon, Patrick Wagner – 1 March 1988 – The effects of ethanol on liver regeneration are poorly understood. Acute and chronic exposure to ethanol have been found to exert opposite effects on the induction of ornithine decarboxylase, the rate‐limiting enzyme for polyamine biosynthesis. Polyamines are necessary for DNA synthesis and liver regeneration after chemical or surgical liver injury.

Philippe Mavier, Anne‐Marie Preaux, Bernard Guigui, Marie‐Claude Lescs, Elie‐Serge Zafrani, Daniel Dhumeaux – 1 March 1988 – Human polymorphonuclear neutrophils, when exposed to soluble or particulate stimuli, can destroy various types of cells. The aim of this study was to investigate their toxicity against hepatocytes. Human polymorphonuclear neutrophils were incubated in basal conditions and after stimulation with 5 mg per ml opsonized zymosan in the presence of rat hepatocytes isolated by collagenase digestion.