Mauro Pirovino, Otfried Müller, Thomas Zysset, Ueli Honegger – 1 May 1988 – Morphological and biochemical investigations were performed in guinea pigs after 1, 3, 5 and 16 weeks of amiodarone feeding. The most prominent morphological finding was an increase in dense bodies in hepatocytes, Kupffer cells and in bile duct epithelia, reaching a maximum after 5 weeks of treatment according to morphometric analysis. Similar time courses were observed for the serum and liver tissue concentrations of amiodarone and desethylamiodarone and the—albeit minimal—extent of hepatocellular necrosis.

Helmut Keller, Vera Bezjak, Beatrice Stegaru, Jan Buss, Eggert Holm, Dieter L. Heene – 1 May 1988 – Cardiovascular alterations such as increased heart rate, high cardiac output, reduced systemic vascular resistance, and in most of the cases, increased contractility parameters have been recognized in patients with advanced liver disease.

1 May 1988

Yi‐Ming Chen, Cheng‐Po Hu, Pao‐Huei Chen, Ming‐Huey H. Chu, Yang‐Te Tsai, Shou‐Dong Lee, Chungming Chang – 1 May 1988 – In order to study hepatocellular carcinoma‐associated antigens, screening of sera and ascites was done from hepatocellular carcinoma patients having antibodies reactive with three hepatocellular carcinoma cell lines (PLC/PRF/5, Hep 3B and HA22T/VGH). The indirect immunofluorescent antibody test was used.

William C. Duane, Ingemar Björkhem, Jan Neal Hamilton, Susan M. Mueller – 1 May 1988 – During biosynthesis of bile acid, carbons 25–26–27 are removed from the cholesterol side chain. Side‐chain oxidation begins either with hydroxylation at the 26‐position, in which case the three‐carbon fragment is released as propionic acid, or with hydroxylation at the 25‐position, in which case the three‐carbon fragment is released as acetone.

Alessandra Franco, Vincenzo Barnaba, Piergiorgio Natali, Clara Balsano, Antonino Musca, Francesco Balsano – 1 May 1988 – We analyzed whether normal human hepatocytes, which normally do not display Class II major histocompatibility complex antigens, can be induced to express them in vitro, and whether this induction has an in vivo counterpart in chronic liver diseases. While both α‐ and γ‐interferon induced expression of Class I antigens, only γ‐interferon induced expression of Class II antigens on hepatocytes in vitro.

Santiago J. Munoz, Steven B. Nagelberg, Paul J. Green, John D. Angstadt, Shuin L. Yang, Bruce E. Jarrell, Willis C. Maddrey – 1 May 1988 – We observed ectopic soft tissue calcification affecting seven patients following orthotopic liver transplantation. The cause of such calcification is unknown, but potential pathogenetic factors include hyperparathyroidism, calcium administered during and following surgery, renal failure, acid‐base changes and citrate in fresh frozen plasma.

Tomasz I. Michalak, Norma D. Churchill – 1 May 1988 – The extent of association between woodchuck hepatitis virus surface antigen and host hepatocyte plasma membrane in chronic hepatitis was studied. Purified membranes containing the antigen were treated with various agents which perturb plasma membrane constituents to elute woodchuck hepatitis virus surface antigen. The products from disrupted membranes were analyzed by sedimentation in sucrose gradients and tested to identify the antigen reactivity.

Wanjin Hong, Anh Van Le, Darrell Doyle – 1 May 1988 – The asialoglycoprotein receptor, the hepatic binding lectin for galactose‐terminated glycoproteins, has been isolated and characterized from human, rabbit and rat liver. Several recent studies have shown the existence of the same receptor in murine liver. However, the biochemical structure of the receptor in murine liver has not been resolved. In this paper, we describe the identification and purification of the receptor for asialoglycoproteins from murine liver.

Bruno H. Ch. Stricker, A. P. Roeland Blok, Frans H. J. Claas, Geert E. Van Parys, Valeer J. Desmet – 1 May 1988 – Fifty cases of nitrofurantoin‐associated hepatic injury and two cases of nifurtoinol (hydroxymethylnitro‐furantoin)‐associated hepatic injury reported to the Netherlands Centre for Monitoring of Adverse Reactions to Drugs were analyzed in detail. In 38 cases, a causal relationship was considered likely [i.e., “highly probable” (n = 4), “probable” (n = 23) or “possible” (n = 11)].