Acetaminophen hepatotoxicity and targeted rescue: A model for specific chemotherapy of hepatocellular carcinoma

George Y. Wu, Catherine H. Wu, Mark I. Rubin – 1 September 1985 – We have taken advantage of the presence of hepatic receptors for galactose‐terminal (asialo‐)glycoproteins to achieve targeted rescue of differentiated hepatocytes from acetaminophen‐induced toxicity in vitro. To accomplish this, a conjugate was formed by covalent coupling of N‐acetylcysteine (an acetaminophen antagonist) to galactose‐terminal (asialo‐)fetuin.

Polycythemia and the budd‐chiari syndrome: Study of serum erythropoietin and bone marrow erythroid progenitors

Victor Georges Levy, Agnès Ruskone, Claude Baillou, Diana Thierman‐Duffaud, Albert Najman, Georges Albert Boffa – 1 September 1985 – The mechanism of polycythemia associated with the Budd‐Chiari syndrome is unknown. Erythropoiesis in 10 patients with Budd‐Chiari syndrome was studied in an attempt to distinguish prior unrecognized polycythemia vera from secondary polycythemia.

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