Charles S. Davidson, Wade Volwiler – 1 September 1985

George Y. Wu, Catherine H. Wu, Mark I. Rubin – 1 September 1985 – We have taken advantage of the presence of hepatic receptors for galactose‐terminal (asialo‐)glycoproteins to achieve targeted rescue of differentiated hepatocytes from acetaminophen‐induced toxicity in vitro. To accomplish this, a conjugate was formed by covalent coupling of N‐acetylcysteine (an acetaminophen antagonist) to galactose‐terminal (asialo‐)fetuin.

1 September 1985

Charles S. Davidson – 1 September 1985

Philip Aisen – 1 September 1985

Sylvie Naveau, Thierry Poynard, Annie Abella, Jean‐Pierre Pignon, Alain Poitrine, Hélène Agostini, Othar Zourabichvili, Jean‐Claude Chaput – 1 September 1985 – The aim of this study was to assess prospectively the prognostic value of serum fibronectin in 114 alcoholic cirrhotic patients and to compare serum fibronectin with other prognostic variables. The Cox model and log‐rank test were used to compare survival rates at 1 year.

Osamu Yokosuka, Masao Omata, Fumio Imazeki, Kunio Okuda, Jesse Summers – 1 September 1985 – Twenty patients with HBeAg‐positive chronic liver disease were given large doses of recombinant leukocyte interferon for 4 weeks. Changes of hepatitis B virus DNA in livers and sera were analyzed by the molecular hybridization technique in paired biopsies obtained before and 2 weeks after treatment. Serum hepatitis B virus DNA was examined before, during and after the treatment until 4 weeks post‐interferon.

Akinori Tsubouchi, Kentaro Yoshioka, Shinichi Kakumu – 1 September 1985 – Studies were undertaken to evaluate whether antiidiotypic antibody against antiliver‐specific membrane lipoprotein is related to the disease activity of patients with hepatitis. Sera from normal individuals, patients with viral hepatitis and medical staffs were depleted of antiliver‐specific membrane lipoprotein antibody by absorbing with liver‐specific membrane lipoprotein‐bearing cell line SK‐Hep‐1.

Adrian B. Bomford, Hamish N. Munro – 1 September 1985 – Transferrin, its receptor and the entry of iron into the cell have sprung into prominence because of recent evidence that proliferation of various cell types involves regulation of this sequence of events, as evidenced especially by changes in receptor number. A third component functionally linked to transferrin and its receptor is the intracellular iron‐storage protein, ferritin, which ensures against toxic levels of free ferrous iron, which might otherwise cause peroxidative damage to cell membranes and other cell structures (1).

Erik Christensen, Poul Schlichting, Lis Fauerholdt, Erik Juhl, Hemming Poulsen, Niels Tygstrup, The Copenhagen Study Group for Liver Diseases – 1 September 1985 – The time change of laboratory variables in cirrhosis was studied by analysis of data from 488 patients with cirrhosis included in a controlled clinical trial of long‐term prednisone vs. placebo.