Establishment of a cell line from a woodchuck hepatocellular carcinoma

Masashi Unoura, Kenichi Kobayashi, Kenichi Fukuoka, Fumiaki Matsushita, Hideo Morimoto, Tohru Oshima, Shuichi Kaneko, Nobu Hattori, Seishi Murakami, Hiroshi Yoshikawa – 1 November 1985 – A new cell line derived from a woodchuck hepatocellular carcinoma serially transplanted in athymic nude mice has been established and named WH257GE10. The original tumor in the nude mouse system produces woodchuck hepatitis surface antigen and albumin. In addition, woodchuck hepatitis virus DNA is integrated into cellular DNA.

Hepatitis B vaccine: Low postvaccination immunity in hospital personnel given gluteal injections

Karen L. Lindsay, David A. Herbert, Gary L. Gitnick – 1 November 1985 – Although other investigators have found excellent response rates to the hepatitis B vaccine, we report here an unusually low rate of seroconversion following hepatitis B vaccination in a group of apparently healthy medical center personnel. Only 67% of these individuals developed adequate postvaccination antibodies to HBsAg, in contrast to 85 to 96% in other studies.

A randomized study of the effects of adenine arabinoside 5′‐monophosphate (short or long courses) and lymphoblastoid interferon on hepatitis B virus replication

Anna S. F. Lok, David M. Novick, Peter Karayiannis, Arthur A. Dunk, Sheila Sherlock, Howard C. Thomas – 1 November 1985 – A previous randomized controlled study has shown a 30% rate of HBe antigen/antibody serocon‐version within 1 year of a month course of adenine arabinoside‐5′‐monophosphate; no seroconversion occurred in the control group.

On the pathogenesis of focal nodular hyperplasia of the liver

Ian R. Wanless, Carolyn Mawdsley, Ronald Adams – 1 November 1985 – Fifty‐one focal nodular hyperplasia lesions from 36 patients were examined histologically. Serial sections and three‐dimensional models were studied in selected cases. Lesions were multiple in 19% of patients. Thirty‐four patients were female. One case had 11 focal nodular hyperplasia lesions and 7 hemangiomata in the liver. Three had astrocytoma and one had anomalous pulmonary venous drainage.

Subscribe to