Bruno Clement, Jean‐Alexis Grimaud, Jean‐Pierre Campion, Yves Deugnier, Andre Guillouzo – 1 March 1986 – Three collagen types (I, III and IV) and fibronectin were localized in normal and alcoholic human liver by light and electron microscopy using the indirect immunoperoxidase technique. In normal liver, most of the bundles of collagen fibers stained for type pro‐III collagen while only a few reacted for type I. Basement membranes stainedfor type IV collagen which formed discontinuous discrete deposits in sinusoids.

Tetsuo Yamamoto, Takeaki Suou, Chisato Hirayama – 1 March 1986 – Of 143 patients with pulmonary tuberculosis receiving isoniazid therapy, 52 (36%) had a transient elevation in serum aminotransferases. Among 74 patients taking isoniazid, rifampicin and streptomycin, 35 (47%) had such an increase, while of 69 patients taking isoniazid, amino‐salicylic acid and streptomycin, 17 (24%) did; this difference was significant. Isoniazid therapy could be continued in all patients with the abnormal test results.

Richard S. Aycock, Jerome M. Seyer – 1 March 1986

1 March 1986

Mark A. Feitelson – 1 March 1986 – The X region in hepatitis B virus DNA potentially encodes a polypeptide 154 amino acids in length. Two synthetic peptides spanning residues 100 to 115 (peptide 99) and 115 to 131 (peptide 100) in a hydrophilic domain within the carboxy terminal third of theproposed gene product were made and used to raise peptide antisera in rabbits.

Douglas R. Labrecque, Joan M. Muhs, Larry I. Lutwick, Robert F. Woolson, Walter R. Hierholzer – 1 March 1986 – A prospective study was designed to determine the risk of hepatitis B transmission from health care deliverers to patients in the hospital setting. Six chronic carriers of hepatitis B were identified: 2 surgeons, 1 dialysis nurse, 1 pediatric ICU nurse, 1 pharmacist and 1 orderly. Three of the six were HBeAg‐positive. Two of the HBeAG‐positive chronic carriers also had circulating hepatitis B virus DNA and accounted for approximately two‐thirds of the total patient contacts.

Sylvie Naveau, Gilles Pelletier, Thierry Poynard, Pierre Attali, Alain Poitrine, Catherine Buffet, Jean‐Pierre Etienne, Jean‐Claude Chaput – 1 March 1986 – Between March 1982 and September 1983, 40 inpatients (25 men and 15 women, mean age 53 years) with alcoholic cirrhosis and total serum bilirubin ⩾5 mg per dl were studied. Those with hepatocellular carcinoma, renal failure, hyponatremia, septicemia, spontaneous bacterial peritonitis, gastrointestinal bleeding, and hepatic coma were excluded. Patients were studied for 28 days.

Nelson Fausto – 1 March 1986

Marek J. Nowicki, Myron J. Tong, Prem V. Nair, Douglas Stevenson – 1 March 1986 – In vitro synthesis of the anti‐HBc, anti‐HBs and polyclonal IgG and IgM classes of antibodies were determined from supernatants of peripheral blood mononuclear cells cultured in the presence of pokeweed mitogen. Thirty‐seven patients with chronic hepatitis B and 10 healthy control subjects whose sera were positive for anti‐HBs formed the study group. Twenty‐four of 37 patients showed histologic evidence of chronic active hepatitis B while the remaining 13 patients had chronic persistent hepatitis B.

Giovambattista Pinzello, Roberto Virdone, Francesca Lojacono, Maddalena Ciambra, Gabriella Dardanoni, Germana Fiorentino, Loredana Riccobono, Luigi Pagliaro – 1 March 1986 – Ascitic fluid pH and arterial‐ascitic fluid pH gradient were compared to ascitic fluid polymorphonuclear cell count in 84 patients with cirrhotic ascites and in 12 with malignant ascites to assess their role as diagnostic tests for spontaneous bacterial peritonitis and to clarify the relationship between ascitic fluid pH and lactate.