Burton Combes – 1 May 1986

Emanuel Sikuler, Roberto J. Groszmann – 1 May 1986 – It is not known whether the hyperdynamic state which has been observed in several experimental models and in patients with portal hypertension reflects a temporary phase during the evolution of the portal hypertensive syndrome or is an expression of a permanent steady state. A hemodynamic study was performed in a group of rats with long‐standing portal hypertension induced by portal vein constriction performed 6.2 ± 0.1 months earlier.

Harold O. Conn – 1 May 1986

Masahiro Arakawa, Masayoshi Kage, Shin‐Ichi Matsumoto, Yasuhisa Akagi, Takemi Noda, Kazunori Fukuda, Toshiro Nakashima, Kunio Okuda – 1 May 1986 – Histological examination of the wall of the stomach and esophagus in patients with hepatocellular carcinoma associated with cirrhosis demonstrated intravariceal tumor thrombi in 13 (23.6%) of 55 cases studied. There were distant hematogenous metastases in 31 of them, of whom 12 (38.7%) had variceal tumor thrombi. Tumor thrombi were of varying sizes, and tumor cells appeared either intact, degenerated or necrotic.

I. A. Sherman, M. M. Fisher – 1 May 1986 – Experiments were undertaken to evaluate the role of intravital epifluorescent TV microscopy in the study of the hepatic transport of sodium fluorescein and fluorescently labeled sodium glycocholate in rats and hamsters.

Lynwood Hammers – 1 May 1986

Agata Budkowska, Pascal Dubreuil, Francis Capel, Jacques Pillot – 1 May 1986 – A solid‐phase radioimmunoassay involving specific antibody was developed for determination of the pre‐S gene‐encoded epitopes of hepatitis B virus and anti‐pre‐S antibody in sera of hepatitis B patients. The reaction for pre‐S determinants associated with HBsAg was quantitatively inhibited by soluble, polymerized human serum albumin, and the lower limit of the assay was about 1.6 ng of HBsAg per ml.

Bruce A. Runyon, Dennis E. Van Epps – 1 May 1986 – Serial ascitic fluid samples were obtained during diuresis in seven patients with portal hypertension‐related ascites. The samples were tested for concentrations of total protein, CH100, C3 and C4 as well as for in vitro opsonic activity. These parameters were all found to increase to a statistically significant degree when the initial specimen was compared to the final specimen: total protein=1.5 vs. 2.7 gm per dl; CH100=9.3 vs. 20.2 units per ml; C3=13.4 vs. 23.8 mg per dl; C4=1.9 vs. 3.6 mg per dl, and opsonic activity=0.8 vs.

Andrew Stolz, Yuichi Sugiyama, John Kuhlenkamp, Bruce Osadchey, Tadataka Yamada, William Belknap, William Balistreri, Neil Kaplowitz – 1 May 1986 – Rat liver efficiently extracts bile acids from the portal blood and rapidly excretes them into bile. Little is known about the process by which bile acids traverse the liver cell from the sinusoidal to the canalicular membrane. In order to begin to define this process, we recently identified a pair of similar monomeric (33 kilodalton) cytosolic bile acid binding proteins (bile acid binders I and II, J. Biol. Chem.

Shin Ohnishi, Tohru Murakami, Takashi Moriyama, Keiji Mitamura, Michio Imawari – 1 May 1986 – Both androgen and estrogen receptors were studied in human hepatocellular carcinoma and noncancerous liver tissue surrounding it. Androgen receptor was detected in the cytosol and/or nucleosol of 4 of 8 cancerous tissues and 1 of 6 noncancerous tissues. The levels of androgen receptor in hepatocellular carcinomas ranged from 3.4 to 37.6 fmoles per mg protein with dissociation constants (Kd) of 0.226 − 51.3×10−9M.