Sheri M. Krams, Charles D. Surh, Ross L. Coppel, Aftab Ansari, Boris Ruebner, M. Eric Gershwin – 1 March 1989 – The availability of recombinant mitochondrial autoantigens may permit the experimental study of the pathophysiology of primary biliary cirrhosis. Previously, we demonstrated that high‐titer antibodies to the 74 kD mitochondrial autoantigen dihydrolipoamide acetyltransferase could be generated when BALB/c mice were immunized with purified recombinant protein.

Bruce R. Bacon, Robert S. Britton, Rosemary O'Neill – 1 March 1989 – Peroxidative decomposition of organelle membrane phospholipids with subsequent organelle dysfunction is a postulated mechanism of liver cell injury in parenchymal iron overload. We studied the effects of different α‐tocopherol concentrations on hepatic mitochondrial lipid peroxidation and oxidative metabolism in rats with chronic dietary iron overload.

Alexander L. Gerbes, Heinrich Wernze, Rainer M. Arendt, Angelika Riedel, Tilman Sauerbruch, Gustav Paumgartner – 1 March 1989 – The role of the atrial natriuretic factor and of the main counteracting sodium‐retaining principle, the renin‐aldosterone system, in acute volume regulation of cirrhosis of the liver has been investigated. Central volume stimulation was achieved in 21 patients with cirrhosis, 11 without and 10 with ascites, and 25 healthy controls by 1‐hr head‐out water immersion.

1 March 1989

S. C. Arya – 1 March 1989

Christian Bréchot – 1 March 1989

Seymour Mishkin, Shaindel Y. Mishkin, Julius Erdstein – 1 March 1989 – The liver is a steroid‐responsive organ and contains high levels of androgen receptors (AR). The present study investigated cytosolic AR concentrations in diseased human liver obtained by needle biopsy. Insufficient tissue was available for full Scatchard analysis. Previous studies have shown the binding affinity of the liver AR to be sufficiently constant to allow the use of a single saturating dose analysis, using 3H‐mibolerone as the active ligand, for the estimation of binding sites.

Takashi Matsumata, Takashi Kanematsu, Kenji Takenaka, Yasuhiro Yoshida, Takashi Nishizaki, Keizo Sugimachi – 1 March 1989 – Using selective angiograms of the liver, we analyzed the patterns of intrahepatic recurrence of hepatocellular carcinomas following curative surgery. In 33 patients with intraheptaic recurrences, seven patients (21%) had a recurrence near the resected hepatic stump. The remaining 26 had either a nodular recurrence in segments away from the resected margin or a widespread multinodular recurrence in the liver remnant.

Guy Renaud, Robert L. Hamilton, Richard J. Havel – 1 March 1989 – Rats were treated with 17α‐ethinyl estradiol to induce high levels of low‐density lipoprotein receptors in hepatocytes. When these rats were given intravenous injections of low‐density lipoprotein‐colloidal gold complexes, most of the gold (labeled with 195Au) appeared to be taken up by Kupffer cells, as were complexes of colloidal gold with albumin or polyvinylpyrrolidone.

Sien‐Sing Yang, Jacob Korula, James E. Sundheimer, Anthony J. Keyser – 1 March 1989 – Digoxin‐like immunoreactive substances, which cross‐react with digoxin antibody, have been found to have natriuretic effect and Na+,K+‐ATPase inhibitory effect. The role of digoxin‐like immunoreactive substances in chronic liver disease was studied by radioimmunoassay in 63 serum and 60 urine samples from 58 patients with chronic liver disease and compared with 16 controls.