The effect of cimetidine on hepatic drug elimination in cirrhosis
Donald C. Nelson, George R. Avant, K. Vincent Speeg, Anastacio M. Hoyumpa, Steven Schenker – 1 March 1985 – Both cimetidine therapy and cirrhosis individually interfere with normal elimination of various drugs. Cimetidine is often prescribed in patients with cirrhosis but there is incomplete data on its effect on drug elimination in cirrhotics. The purpose of this study was to address this issue. Eight stable cirrhotics were studied prior to and following 7 days of cimetidine administration, (300 mg orally q.i.d.).