Monoclonal antibodies and hepatoma
K. Robert McIntire – 1 May 1985
The effect of concentration on hepatic transport of exogenous epidermal growth factor
Susan Jo Burwen, Mary E. Barker, Ira S. Goldman, Albert L. Jones – 1 March 1985 – Epidermal growth factor (EGF), taken up by rat liver hepatocytes, is primarily transported to the lysosomes and degraded. However, a small but significant percentage of endocytosed EGF is transported by a nonlysosomal pathway and is secreted intact into bile. There is no information as to the mechanisms that regulate the selection of transport pathway and thereby determine the different metabolic fates for EGF.
Endocytosis and binding of asialoorosomucoid by hepatocytes from rats with jejunoileal bypass
Nathalie Serbource‐Goguel/Seta, Béatrice Borel, Michèle Dodeur, Pierre Scarmato, Benoit Bourel, Jeanne Feger, Geneviève Durand – 1 March 1985 – Rats with Jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoo‐rosomucoid in serum has been determined.
The effects of colchicine and vinblastine on the biliary excretion of carcinoembryonic antigen
Peter Thomas, Paul F. O'Neil, Norman Zamcheck – 1 March 1985 – The biliary output of carcinoembryonic antigen (CEA) in bile fistula rats following treatment with the microtubule poisons vinblastine and colchicine increased 3‐fold over a 4‐hr period. Cytochalasin B and the inactive colchicine derivative lumicolchicine had no effect. These treatments did not effect the rate of CEA clearance from the circulation. Biliary output of low molecular weight fragments from CEA degradation was decreased in the presence of colchicine and vinblastine.
Respective roles of hypoxia and halothane metabolism in halothane‐induced liver injury in rats
Hitoshi Hatano, Fumio Nomura, Kunihiko Ohnishi, Toshihiko Iijima, Akira Hayasaka, Shinji Iida, Hirofumi Koen, Kunio Okuda – 1 March 1985 – To evaluate the respective roles of halothane metabolism and hypoxia in rats with halothane hepatotoxicity, experiments were designed with special reference to blood gas. After pretreatment with phenobarbital (80 mg per kg., i.p.) for four consecutive days, rats were exposed to 1.0% halothane under a mildly hypoxic condition (FiO2 = 14%) for 2 hr.
Masthead
1 March 1985
Temporal relationship between hyperaldosteronism, sodium retention and ascites formation in rats with experimental cirrhosis
Wladimiro Jiménez, Antonio Martinez‐Pardo, Vicente Arroyo, Jordi Bruix, Antoni Rimola, Joan Gaya, Francisca Rivera, Joan Rodés – 1 March 1985 – To investigate the role of aldosterone in sodium retention and ascites in cirrhosis, the urinary sodium excretion, sodium balance and urinary excretion of aldosterone‐18‐glucuronide (UAidV) were serially measured in 11 rats undergoing cirrhosis induction with carbon tetrachloride (CT) and phenobarbital (CT rats) and in 10 control rats which received phenobarbital.
Pharmacokinetic‐hemodynamic interactions between vasopressin and nitroglycerin: Comparison between intravenous and cutaneous routes of nitrate delivery
Andres T. Blei, Steve Friedman, Jeanne Gottstein, Gary Robertson, Ho‐Leung Fung – 1 March 1985 – Addition of nitroglycerin (NTG) improves the hemodynamic response to vasopressin and may thus be useful in the treatment of gastrointestinal hemorrhage. We studied in the rat the influence of vasopressin on the disposition of a constant intravenous infusion of NTG and the cutaneous absorption of NTG ointment. The effect of NTG on the pharmacokinetics of vasopressin was also defermined. Animals were divided into four groups: control, NTG, vasopressin and vasopressin + NTG.