S. R. Parekh, B. D. Patel, S. R. Damle, G. M. Thanki, D. Khutti – 1 January 1983 – Alkaline phosphatase (ALP) isoenzyme composition was studied in sera and liver from patients with Indian childhood cirrhosis (ICC). A typical pattern consisting of a fast‐moving anodal preliver band with slower moving diffuse liver and placental bands followed by an intestinal band was consistently observed in sera of patients in all stages of ICC and in pregnant mothers of index ICC patients. ICC liver ALP was relatively heat‐stable and inhibited by L‐phenylalanine and L‐leucine.

Richard H. Renston, Gyula Zsigmond, Robin A. Bernhoft, Susan J. Burwen, Albert L. Jones – 1 January 1983 – The vesicular transport system for biliary secretion of plasma‐derived proteins was investigated in rats with chronic bile duct obstruction. Horseradish peroxidase, previously demonstrated to be a suitable tracer for vesicular transport, was employed in these studies.

Hans Popper – 1 January 1983

1 January 1983

1 January 1983

1 January 1983

David J. Greenblatt – 1 January 1983

Riccardo Meliconi, Federico Miglio, M. Valeria Stancari, Mario Baraldini, G. Francesco Stefanini, Giovanni Gasbarrini – 1 January 1983 – Hepatocytes isolated from 101 biopsies were examined for membrane‐bound IgG. The sera of the patients were tested for anti‐liver‐specific lipoprotein by radioimmunoassay and for liver membrane autoantibody (by indirect immunofluorescence on isolated rabbit hepatocytes. The seven patients with normal liver or minor nonspecific alterations were negative for membrane IgG and serum antibodies.

Morris Sherman, Nathan M. Bass, John A. H. Campbell, Ralph E. Kirsch – 1 January 1983 – A sensitive and specific radioimmunoassay for human ligandin has been developed and used to study ligandin release into the serum in acute and chronic hepatitis. Serum ligandin concentrations were elevated in 67 of 68 cases of acute viral hepatitis. Ligandin levels frequently returned to normal within the first 2 weeks of illness. The rapid disappearance of ligandin preceded the return to normal of serum SGOT.

Mark A. Zern, Prasanta R. Chakraborty, Nelson Ruiz‐Opazo, Sing H. Yap, David A. Shafritz – 1 January 1983 – A rat albumin cDNA probe (pBR alb 149) was developed in order to investigate the molecular mechanisms responsible for changes in hepatic protein synthesis after chronic administration of ethanol to rats. Rats fed a diet for up to 1 year in which 36% of calories were from ethanol, developed fatty livers but not cirrhosis.