Morris Sherman, John A. H. Campbell, Sally A. Titmuss, Michael C. Kew, Ralph E. Kirsch – 1 January 1983 – Qualitative and quantitative changes in glutathione S‐transferase (GSH‐T) were studied in human hepatocellular carcinoma. GSH‐T specific activity (/imoles per min per mg protein) was variably reduced in hepatocellular carcinoma. Similar changes were seen in “cationic” GSH‐T (ligandin) concentration determined by radioimmunoassay. Immunohistochemical studies with antihuman liver ligandin suggest that positive staining was more frequently found in well‐differentiated tumors.

Robert E. Shank – 1 January 1983

Dominique Bernuau, Edith Rogier, Gérard Feldmann – 1 January 1983 – During the acute inflammatory reaction (AIR), the plasma concentration of several plasma proteins, including fibrinogen, is increased as a result of enhanced production by the liver. Whether this increased production influences the production of the other plasma proteins at the single hepatocyte level is not known.

Junichi Tazawa, Tetsuya Irie, Samuel W. French – 1 January 1983 – To evaluate whether Mallory bodies (MBs) are linked to the induction of the enzyme γ‐glutamyl transferase (GGT), mice were fed 2.5% griseofulvin (GF). The experimental and control mice livers were examined at four time periods, i.e., after 4 months' of GF feeding, 1 month after GF withdrawal and 13 days after GF refeeding, and at sacrifice after 4 months of GF withdrawal. The livers from mice continuously fed GF or control diet for 10 months were also examined.

Dominique L. Delacroix, Gildo Furtado‐Barreira, Bernard De Hemptinne, Jan Goudswaard, Charles Dive, Jean‐Pierre Vaerman – 1 January 1983 – The liver transport of polymeric IgA (plgA) from plasma into bile and the immunohistochemical distribution of secretory component (SC) in the liver were studied in dogs, and compared to those in humans, rats, and rabbits.

Fredric G. Regenstein, Stanford T. Roodman, Robert P. Perrillo – 1 January 1983 – The purposes of this study were 2‐fold: (i) To enumerate peripheral immunoregulatory T cell subsets in untreated patients with chronic hepatitis B virus (HBV) infection and (ii) to examine the relationship between disturbances in the balance of lymphocyte subsets with liver disease and the presence of homosexuality.

Hector Orrego, Yedy Israel, Joan E. Blake, Alan Medline – 1 January 1983 – The prognostic significance of a battery of clinical, laboratory, and histological indicators was assessed in relation to mortality risk in a 1‐year study of 253 patients with alcoholic liver disease, of whom 51 died within such time. The relative risk associated with each abnormality was calculated. A number of abnormalities was found to be statistically associated with a higher risk of death.

Stephen C Wright – 1 January 1983

Suri Anand, Robert R. Schade, Carlos Bendetti, Robert Kelly, Bruce S. Rabin, John Krause, Thomas E. Starzl, Shunzaburo Iwatsuki, David H. Van Thiel – 1 January 1983 – A patient with coexistent hemochromatosis and alpha‐1‐antitrypsin deficiency which led to cirrhosis and death despite adequate therapy for hemochromatosis is reported. Evaluation of the family revealed first degree relatives with iron overload and others with alpha‐1‐antitrypsin deficiency but none with both conditions.

Evangelista Sagnelli, Felice Piccinino, Giuseppe Manzillo, Francesca M. Felaco, Pietro Filippini, Giuseppe Maio, Giuseppe Pasquale, Crescenzo M. Izzo – 1 January 1983 – Two hundred and four patients with biopsy‐proven HBsAg‐positive chronic active hepatitis were treated for at least 2 years with azathioprine, prednisolone or a combination of both, or were untreated. Prevalences of HBeAg, anti‐HBe, and anti‐HBc were 26, 58, and 100%, respectively.