1 September 1986

Kunio Okuda – 1 September 1986 – In order to assess the incidence of hepatocellular carcinoma (HCC) in porphyria cutanea tarda (PCT), 83 patients (77 males, 6 females, mean age 57.4 years) were studied. Thirteen patients (15.7%) had HCC, all of whom were male and cirrhotics with a mean age of 58.5 years. HCC patients showed a statistically significant (P < 0.0005) longer evolution time (23 years since onset of the cutaneous disease) than patients without HCC (9.4 years), while the age of onset was similar in both groups.

Ralph A. Defronzo – 1 September 1986 – Insulin encapsulated in lipid vesicles and targeted to hepatocytes by means of a digalactosy diglyceride moiety [(designated vesicle encapsulated insulin (VEI)] was administered intrave nously to conscious catheterized diabetic dogs to determine the effects on hepatic and extrahepatic glucose utilization.

P. Nico Lelie, Henk W. Reesink, Rob Grijm, Sonja Th. de Jong‐Van Manen, Eveline E. Reerink‐Brongers – 1 September 1986 – The effect of simultaneous administration of hepatitis B immune globulin on the antibody response to a low dose of heat‐inactivated hepatitis B vaccine was investigated in 175 health care workers.

Jeremy S. Wilson, Mark A. Korsten, Charles S. Lieber – 1 September 1986 – This investigation was performed to examine the combined effects of protein deficiency and chronic ethanol consumption on ethanol clearance and hepatic ethanol metabolism of the rat. Protein deficiency alone was associated with reduced ethanol clearance and decreased activity of hepatic alcohol dehydrogenase and the microsomal ethanol‐oxidizing system.

Joost J. van den Oord, Rita De Vos, Valeer J. Desmet – 1 September 1986 – Using a double‐staining immunohistochemical procedure, the topographical relationship between viral antigens on the one hand and the expression of major histocompatibility complex products by hepatocytes on the other hand was analyzed in a series of 19 liver biopsies from patients with chronic hepatitis B virus infection.

Bertram I. Cohen, Erwin H. Mosbach, Charles K. McSherry, Richard J. Stenger, Syoji Kuroki, Beverly Rzigalinski – 1 September 1986 – The effects of a standard rodent chow were compared with those of a semisynthetic diet of known composition (with and without added cholesterol) in the prairie dog model of cholesterol cholelithiasis. Gallstone incidence was 40% higher in animals fed a semisynthetic diet plus cholesterol compared to chow plus cholesterol.

Karen E. Shattuck, Anna Radominska‐Pyrek, Piotr Zimniak, Eugene W. Adcock, Roger Lester, Jan St. Pyrek – 1 September 1986 – 24‐Norlithocholic (3α‐hydroxy‐24‐nor‐5β‐cholan‐23‐oic) acid is the lower homologue of lithocholic acid, a potent cholestatic agent. In order to characterize its cholestatic potential and metabolic fate, 3β‐tritiated 24‐norlithocholate was infused intravenously into adult male Sprague‐Dawley rats prepared with an external biliary fistula.

Deborah Trinder, Evan Morgan, Erica Baker – 1 September 1986 – The mechanisms of iron accumulation by cultured hepatocytes isolated from fetal rat liver (19 days gestation) were investigated using rat transferrin labeled with 125I and 59Fe. The rates of iron and transferrin internalization by the cells were measured by incubating the hepatocytes with the labeled transferrin at 37°C followed by treatment with pronase at 4°C to remove surface‐bound transferrin and iron. Iron internalization increased linearly with time.

Jean‐Jacques Lefrere, Danièle Gozin, Joelle Lerable, Jean‐Pierre Soulier – 1 September 1986