Peter Van Eyken, Raf Sciot, Francesco Callea, Kris Van Der Steen, Philip Moerman, Valeer J. Desmet – 1 November 1988 – The development of the intrahepatic bile ducts in man was studied using an immunohistochemical technique on 56 liver specimens ranging in age from 6 weeks of gestation to 8 months after birth. On paraffin sections, two monoclonal anticytokeratin antibodies (CAM 5.2 and KL‐1) that normally stain both hepatocytes and bile duct cells and two polyclonal anticytokeratin antisera that in normal adult liver stain bile ducts only were applied.

Henry C. Bodenheimer, Ronald A. Faris, Colette Charland, Douglas C. Hixson – 1 November 1988 – We have characterized the cell and tissue binding specificity of a newly generated monoclonal antibody, Mab Ku‐1, which shows selective reactivity with rat macrophages and Kupffer cells. The hybridoma secreting Mab Ku‐1 was constructed by fusion of 8653 myeloma cells with spleen cells isolated from a mouse immunized with nonparenchymal liver cells coated with antihepatocyte antibodies.

Katsunori Wada, Fukuo Kondo, Yoichiro Kondo – 1 November 1988 – In order to reveal the precursor lesion of hepatocellular carcinoma, a histopathologic study was performed on 141 cases of liver cirrhosis with or without hepatocellular carcinoma. Exclusive of primary or metastatic hepatocellular carcinoma nodules, 94 nodular lesions (>5 mm) were detected in 53 cirrhotic livers. They consisted of 83 large regenerative nodules and 11 dysplastic nodules.

Richard J. Havel, Robert L. Hamilton – 1 November 1988

Kwang‐Juei Lo, Shou‐Dong Lee, Yang‐Te Tsai, Tzee‐Chung Wu, Cho‐Yu Chan, Gran‐Hum Chen, Ching‐Lan Yeh – 1 November 1988 – In an attempt to evaluate the long‐term immunogenicity and efficacy of plasma‐derived hepatitis B vaccine in preventing hepatitis B virus infection, 199 infants born to hepatitis B e antigen‐positive hepatitis B surface antigen‐carrier mothers were found to be antibody to HBsAg‐positive (± 10 mIU per ml) 2 months after the first booster of hepatitis B vaccination at age 1, and their serum HBsAg and anti‐HBs were rechecked annually to ages 3 to 5.

Antonio Ponzetto, Francesco Negro, Hans Popper, Ferruccio Bonino, Ronald Engle, Mario Rizzetto, Robert H. Purcell, John L. Gerin – 1 November 1988 – Five consecutive passages of hepatitis delta virus in hepatitis B virus carrier chimpanzees were performed in order to further characterize the infectious and pathogenic nature of this naturally occurring defective virus. Three animals received identical inocula at fourth passage in order to assess individual animal variation as a factor in the course of infection and disease.

Geoffrey M. Dusheiko – 1 November 1988 – In a previous study a partial inhibition of viral replication was observed in HBeAg‐positive patients after acyclovir (ACV) treatment.

Hastings K. Wright – 1 November 1988

Guido Piai, Livio Cipolletta, Max Claar, Giampiero Marone, Maria Antonietta Bianco, Giovanni Forte, Giuseppe Iodice, Daniele Mattera, Mauro Minieri, Pietro Rocco, Lorenzo Michele Santoro, Gabriele Mazzacca – 1 November 1988 – In this prospective, multicenter trial, 140 cirrhotic patients with no previous upper gastrointestinal bleeding and with esophageal varices endoscopically judged to be at high risk of hemorrhage were randomized to receive either sclerotherapy or conservative treatment for the prevention of first variceal bleeding. The end‐points of the study were bleeding and death.

Erica Villa, Grazia M. Baldini, Gian Paolo Rossini, Claudio Pasquinelli, Margherita Melegari, Elisabetta Cariani, Cristina Tata, Stefano Bellentani, Alberto Ferrari, Federico Manenti – 1 November 1988 – The hepatic cytosolic estrogen receptor content was measured in liver samples from patients with normal livers and from patients with nonalcoholic cirrhosis, alcoholic cirrhosis and alcoholic hepatitis. The estrogen receptor content of normal liver was 5.2 ± 3.5 fmoles per mg of cytosolic protein.