The dietary prevention of hepatic coma in eck fistula dogs: Ammonia and the carbohydrate to protein ratio

L. Zieve, F. J. Zieve – 1 January 1987 – The conventional animal model of human portal systemic encephalopathy is the dog with Eck fistula. Dogs fed standard dog chow after Eck fistula manifest anorexia, weight loss, hepatic atrophy and encephalopathy. This study was done to determine the natural history of dogs undergoing Eck fistulas when adequate nutrition is maintained with a palatable diet.

Cerebral CT scan abnormalities in cholestatic and hepatocellular disease and their relationship to neuropsychologic test performance

Patricia Bernthal, Amy Hays, Ralph E. Tarter, David Van Thiel, James Lecky, Andrea Hegedus – 1 January 1987 – Forty‐nine nonalcoholic cirrhotic patients, on whom cranial CT scans were available, were administered a battery of neuropsychological tests. Although none of the subjects exhibited clinical signs or symptoms of hepatic encephalopathy, quantification of the CT scan image implicated cerebral edema and cortical atrophy. In addition numerous significant correlations were observed between the CT variables and neuropsychological test performance.

Orthotopic liver transplantation for type I Crigler‐Najjar syndrome

Stuart S. Kaufman, R. Patrick Wood, Byers W. Shaw, Rodney S. Markin, Philip Rosenthal, Bruno Gridelli, Jon A. Vanderhoof – 1 November 1986 – A neurologically normal 3‐year‐old girl with Type I Crigler‐Najjar syndrome was successfully treated with orthotopic liver transplantation. Preoperative serum bilirubin concentrations as high as 31 mg per dl were not diminished with phenobarbital or phototherapy.

Permeability characteristics of the guinea pig biliary apparatus

Nicola Tavoloni, Herman R. Wyssbrod, Mary Jane T. Jones – 1 November 1986 – To determine the mechanism and pathway of entry of polar nonelectrolytes into bile, we studied first the permeation of [3H]H2O, [14C]urea, [14C]erythritol, [14C]mannitol, [3H]sucrose, [3H]inulin and [3H]dextran across an isolated, in situ perfused segment of the guinea pig's extrahepatic bile duct. All of these molecules, except [3H]dextran, permeated the bile duct. The diffusive permeability coefficients (cm per sec per 106) ranged from 248 for [3H]H2O to 1.2 for [3H]inulin.

Regulation of low density lipoprotein receptor activity in primary cultures of human hepatocytes by serum lipoproteins

Louis M. Havekes, Hans Verboom, Elly de Wit, Sing Hiem Yap, Hans M. G. Princen – 1 November 1986 – The low density lipoprotein receptor activity was measured in primary cultures of human hepatocytes. The receptor‐mediated association and degradation of low density lipoprotein increased gradually up to 140 and 190%, respectively, upon incubation of the cells with increasing amounts of whole serum (up to 100%).

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