Patricia Bernthal, Amy Hays, Ralph E. Tarter, David Van Thiel, James Lecky, Andrea Hegedus – 1 January 1987 – Forty‐nine nonalcoholic cirrhotic patients, on whom cranial CT scans were available, were administered a battery of neuropsychological tests. Although none of the subjects exhibited clinical signs or symptoms of hepatic encephalopathy, quantification of the CT scan image implicated cerebral edema and cortical atrophy. In addition numerous significant correlations were observed between the CT variables and neuropsychological test performance.

Stuart S. Kaufman, R. Patrick Wood, Byers W. Shaw, Rodney S. Markin, Philip Rosenthal, Bruno Gridelli, Jon A. Vanderhoof – 1 November 1986 – A neurologically normal 3‐year‐old girl with Type I Crigler‐Najjar syndrome was successfully treated with orthotopic liver transplantation. Preoperative serum bilirubin concentrations as high as 31 mg per dl were not diminished with phenobarbital or phototherapy.

Caroline A. Riely – 1 November 1986

Nicola Tavoloni, Herman R. Wyssbrod, Mary Jane T. Jones – 1 November 1986 – To determine the mechanism and pathway of entry of polar nonelectrolytes into bile, we studied first the permeation of [3H]H2O, [14C]urea, [14C]erythritol, [14C]mannitol, [3H]sucrose, [3H]inulin and [3H]dextran across an isolated, in situ perfused segment of the guinea pig's extrahepatic bile duct. All of these molecules, except [3H]dextran, permeated the bile duct. The diffusive permeability coefficients (cm per sec per 106) ranged from 248 for [3H]H2O to 1.2 for [3H]inulin.

Andrew K. Burroughs, Francois d'Heygere, Neil McIntyre – 1 November 1986

Takashi Moriyama, Hiromu Aoyama, Shin Ohnishi, Michio Imawari – 1 November 1986 – The effects of supplementation with fibronectin on liver damage and survival in rats with galactosamine‐induced liver failure were studied.

Louis M. Havekes, Hans Verboom, Elly de Wit, Sing Hiem Yap, Hans M. G. Princen – 1 November 1986 – The low density lipoprotein receptor activity was measured in primary cultures of human hepatocytes. The receptor‐mediated association and degradation of low density lipoprotein increased gradually up to 140 and 190%, respectively, upon incubation of the cells with increasing amounts of whole serum (up to 100%).

Robert P. Perrillo, Fredric G. Regenstein – 1 November 1986

Karen L. Lindsay, J. Anne Nizze, Ronald Koretz, Gary Gitnick – 1 November 1986 – Numerous tests to detect anti‐HBc IgM have been developed and shown to have different degrees of sensitivity and specificity. One of these assays, Corzyme®‐M (Abbott Laboratories, North Chicago, Ill.), recently became commercially available. The present study was undertaken to evaluate the clinical utility of this anti‐HBc IgM test in establishing the diagnosis of acute hepatitis B using sera from a group of 42 prospectively followed individuals who had been exposed to hepatitis B virus.

Alan F. Hofmann, Nicholas F. Larusso – 1 November 1986