Regulation of the hepatic transferrin receptor in hereditary hemochromatosis

Martin Lombard, Adrian Bomford, Miriam Hynes, Nikolai V. Naoumov, Stephanie Roberts, John Crowe, Roger Williams – 1 January 1989 – The liver is the main site of iron accumulation and pathologic sequelae in hereditary hemochromatosis. Whether this is a result solely of inappropriately increased absorption of iron by the gastrointestinal tract or a more generalized regulatory failure of iron balance is unknown.

Acinar heterogeneity of fatty acid binding protein expression in the livers of male, female and clofibrate‐treated rats

Nathan M. Bass, Mary E. Barker, Joan A. Manning, Albert L. Jones, Robert K. Ockner – 1 January 1989 – Liver fatty acid binding protein may play a role in the intracellular transport and compartmentation of long‐chain fatty acid metabolism. The distribution of liver fatty acid binding protein in the hepatic acinus was determined by means of immunocytochemistry as well as by measurement of liver fatty acid binding protein in cellular protein selectively released from zone 1 and zone 3 cells by means of anterograde and retrograde liver perfusion with digitonin.

Dynamics of hepatic connective tissue matrix constituents during murine schistosoma mansoni infection

Safaa El Meneza, G. Richard Olds, Thomas F. Kresina, Adel A. F. Mahmoud – 1 January 1989 – Hepatic fibrosis is the major clinical sequela of infection with the helminth Schistosoma mansoni. However, little is known regarding its dynamics and regulation in schistosomiasis. The present study presents the dynamics of deposition and resorption of two major extracellular matrix components of fibrosis, glycosaminoglycans and collagens, during the course of experimental S. mansoni infection.

Hepatitis B‐associated polyarteritis nodosa in alaskan eskimos: Clinical and epidemiologic features and long‐term follow‐up

Brian J. McMahon, William L. Heyward, David W. Templin, David Clement, Anne P. Lanier – 1 January 1989 – We analyzed the demographic, clinical, laboratory and histologic features of 13 patients who were diagnosed as having polyarteritis nodosa associated with hepatitis B virus infection over a 12‐year period, 1974 to 1985. All 13 patients were Yupik Eskimos and resided in southwest Alaska, an area hyperendemic for hepatitis B virus infection. The annual incidence of hepatitis B virus‐associated polyarteritis nodosa for this population is 7.7 cases per 100,000 population.

The use of a monoclonal antibody against α‐fetoprotein for the radioimmunodetection of hepatocellular carcinoma

Elsa Springolo, Michael C. Kew, Jan Esser, Margaretha Beyers, Jan D. Conradie, Joseph Levin – 1 January 1989 – The purpose of this study was to investigate the use of a radiolabeled mouse monoclonal antibody (and its F(ab′)2 fragment) against α‐fetoprotein in the scinti‐graphic diagnosis of hepatocellular carcinoma. Twenty‐six southern African Blacks and one Caucasian with hepatocellular carcinoma and four patients with other malignant tumors of the liver were studied.

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