1 September 1986

Didier Houssin, Blanche Bellon, Marie‐Dominique Brunaud, Jean Gugenheim, Abdellatif Settaf, Francesco Meriggi, Jean Emond – 1 September 1986 – Several clinical and experimental findings suggest that liver allografts are less sensitive than other organ allografts to lymphocytotoxic antibodies. In this experimental study in hypersensitized inbred rat recipients, rejection of liver allografts was delayed compared to that of heart allografts. Furthermore, there was a marked decrease in the level of cytotoxic antibodies after liver allografting but not after heart allografting in these animals.

James R. Wood, Albert J. Czaja, Sandra J. Beaver, Stephen Hall, William W. Ginsburg, David K. Kaufman, Harold Markowitz – 1 September 1986 – To assess the frequency and significance of immunoglobulin G antibody to double‐stranded DNA in chronic active hepatitis, 99 patients with severe disease were tested for the antibody by an enzyme‐linked immunosorbent assay of established sensitivity and specificity. Antibody was detected in 56 patients (57%) and occurred with similar frequency in patients with autoimmune (64%), idiopathic (46%) and type B (43%) disease.

Evelyne Jacqz, Stephen D. Hall, Robert A. Branch – 1 September 1986

1 September 1986

Kunio Okuda – 1 September 1986 – In order to assess the incidence of hepatocellular carcinoma (HCC) in porphyria cutanea tarda (PCT), 83 patients (77 males, 6 females, mean age 57.4 years) were studied. Thirteen patients (15.7%) had HCC, all of whom were male and cirrhotics with a mean age of 58.5 years. HCC patients showed a statistically significant (P < 0.0005) longer evolution time (23 years since onset of the cutaneous disease) than patients without HCC (9.4 years), while the age of onset was similar in both groups.

Ralph A. Defronzo – 1 September 1986 – Insulin encapsulated in lipid vesicles and targeted to hepatocytes by means of a digalactosy diglyceride moiety [(designated vesicle encapsulated insulin (VEI)] was administered intrave nously to conscious catheterized diabetic dogs to determine the effects on hepatic and extrahepatic glucose utilization.

P. Nico Lelie, Henk W. Reesink, Rob Grijm, Sonja Th. de Jong‐Van Manen, Eveline E. Reerink‐Brongers – 1 September 1986 – The effect of simultaneous administration of hepatitis B immune globulin on the antibody response to a low dose of heat‐inactivated hepatitis B vaccine was investigated in 175 health care workers.

Jeremy S. Wilson, Mark A. Korsten, Charles S. Lieber – 1 September 1986 – This investigation was performed to examine the combined effects of protein deficiency and chronic ethanol consumption on ethanol clearance and hepatic ethanol metabolism of the rat. Protein deficiency alone was associated with reduced ethanol clearance and decreased activity of hepatic alcohol dehydrogenase and the microsomal ethanol‐oxidizing system.

Joost J. van den Oord, Rita De Vos, Valeer J. Desmet – 1 September 1986 – Using a double‐staining immunohistochemical procedure, the topographical relationship between viral antigens on the one hand and the expression of major histocompatibility complex products by hepatocytes on the other hand was analyzed in a series of 19 liver biopsies from patients with chronic hepatitis B virus infection.