Mark I. Avigan, Gregory Adamson, Jay H. Hoofnagle, E. Anthony Jones – 1 September 1986 – Peripheral blood mononuclear cells from 7 patients with primary biliary cirrhosis and 7 healthy control subjects were studied for their ability to produce antibodies to mitochondrial antigens in vitro. Peripheral blood mononuclear cells were collected by lymphapheresis and cultured with or without pokeweed mitogen for 10 days. The culture supernatants were then tested for antibodies to mitochondrial antigens by both immunofluorescence microscopy and a microtiter ELISA.

David Rzepczynski, Leslie Zieve, Sandra Lindblad, Darlene Lafontaine – 1 September 1986 – The GABAergic agonist, muscimol, and antagonists, picrotoxin and bicuculline, have been studied in rats with chronic portacaval shunts and in rats developing hepatic encephalopathy after massive ischemic necrosis due to hepatic artery ligation within 48 hr of a portacaval shunt. After the chronic portacaval shunt and to a lesser extent in normal rats intraventricular muscimol resulted in chewing and eating behavior, ataxia and loss of balance that lasted 2 to 3 hr.

Charles S. Lieber, Anthony Garro, Maria A. Leo, Ki M. Mak, Theresa Worner – 1 September 1986

Allison R. Jilbert, Christopher J. Burrell, Eric J. Gowans, Paul J. Hertzog, Anthony W. Linnane, Barrie P. Marmion – 1 September 1986 – Cells expressing α2‐interferon were identified by indirect immunofluorescence using both a polyclonal and a monoclonal anti‐α‐interferon antibody reagent.

Fumio Nomura, Hitoshi Hatano, Kunihiko Ohnishi, Bunshiro Akikusa, Kunio Okuda – 1 September 1986 – In order to evaluate the clinical implication of experimental studies on halothane‐induced liver damage in phenobarbital‐treated rats, we studied the clinical records of 315 consecutive patients who underwent brain surgery with halothane anesthesia. After exclusion of subjects with a history of alcoholism or antecedent chronic liver disease, clinical data of 279 patients with normal preoperative transaminase activities were analyzed.

Maud I. Cleton, Erik J. Frenkel, Willem C. de Bruijn, Joannes J. M. Marx – 1 September 1986 – The amounts of phosphorus and iron in various isolated ferritin preparations were investigated by: (i) chemical analysis on ferritin samples and (ii) electron probe X‐ray microanalysis on ferritin particles from the same preparations. A high correlation was found between iron to phosphorus ratios obtained by both methods.

Anastacio M. Hoyumpa – 1 September 1986

Jean‐Pierre Villeneuve, Claire Infante‐Rivard, Michel Ampelas, Gilles Pomier‐Layrargues, P.‐Michel Huet, Denis Marleau – 1 September 1986 – The aminopyrine breath test has been proposed as a quantitative test of hepatic function, but its long‐term prognostic value in patients with cirrhosis has not been determined. The aim of this study was to examine the usefulness of the aminopyrine breath test in assessing prognosis and to compare it with traditional methods of evaluating liver function.

Anne‐Marie Steffan, Jean‐Louis Gendrault, Robert S. McCuskey, Patricia A. McCuskey, André Kirn – 1 September 1986 – Impairment of the phagocytic capacities of Kupffer cells, as is found in Frog Virus 3 hepatitis of mice, allows the endothelial liver cells to take up intravenously inoculated latex particles of 1.0 μm diameter. In vitro experiments with cultivated endothelial cells isolated by collagenase perfusion of the liver and purified by centrifugal elutriation demonstrate that uptake occurs via a typical mechanism of phagocytosis involving pseudopodia.

1 July 1986