M. Sawkat Anwer, Kathleen Nolan – 1 July 1988 – A pH‐stat method was used to characterize H+ efflux pathways in hepatocytes in order to determine if Na+/ H+ and Ca++/H+ exchange are involved in H+ efflux from hepatocytes under basal conditions and if cyclic AMP analogs affect Na+/H+ exchange. Total H+ efflux of freshly prepared hepatocytes ranged from 10 to 15 nmoles per min per mg protein. A part of total H+ efflux (35 to 50%) was dependent on extracellular Na+.

Agesilao D'Arienzo, Luigi Celentano, Alessandro Scuotto, Pasqualina Di Siervi, Vinicio Lombardi, Giovanni Squame, Gabriele Mazzacca – 1 July 1988 – In normal subjects, thallium‐201, administered per rectum, is taken up mainly by the liver (heart/liver ratio in normal subjects: 0.04 to 0.12). It has been claimed that an increased heart/liver ratio is suggestive of portal‐caval shunting and portal hypertension.

Luigi Accatino, Patricia Gavilan – 1 July 1988 – Phospholipids and bile acids, by virtue of their amphiphilic properties, can interact in nonpolar media forming “inverted” structures (micelles) which presumably have an hydrophilic core and might act as diffusional carriers (ionophores) of electrolytes across low dielectric constant media or lipid membranes.

Rebecca W. Van Dyke, Harlan E. Ives – 1 July 1988

Paul S. Lietman – 1 July 1988

Irmin Sternlieb – 1 July 1988 – Experience with liver transplantation for patients with Wilson's disease who have major neurological impairment is limited, and this report describes the results obtained in two such patients. The first was a 30‐year‐old man with a 14‐month history of hepatic and neurological impairment. In spite of treatment with d‐penicillamine, he developed increasing dysarthria, dysphagia, akinesia and rigidity of all four limbs, and required continuous nursing care.

D. W. Bullimore – 1 July 1988

1 July 1988

Anthony J. Stellon, John J. Keating, Philip J. Johnson, Ian G. McFarlane, Roger Williams – 1 July 1988 – Forty‐seven patients with autoimmune chronic active hepatitis in remission on azathioprine and/or prednisolone were entered into a randomized controlled trial to assess the value of azathioprine alone in maintenance of remission.

Bernard H. Davis, Angelina Vucic – 1 July 1988 – Hepatic sinusoidal fat‐storing Ito cells are felt to represent the primary storage site for hepatic vitamin A and may be important collagen‐producing effector cells during hepatic fibrogenesis. The cirrhotic liver generally has a decreased vitamin A content with increased numbers of “transitional” myofibroblasts adjacent to developing fibrous bands. It has been suggested that Ito cells “transform” into these myofibroblasts.