Tadashi Ikeda, Andrew M. L. Lever, Howard C. Thomas – 1 September 1986 – Ninety per cent of patients infected in adult life with the hepatitis B virus clear the virus completely and 10% develop chronic infection. There is evidence for the involvement of interferon in the clearance of acute hepatitis B virus infection.

Johannes Bircher – 1 September 1986

Claudio Tiribelli – 1 September 1986 – Since glucagon can hyperpolarize hepatic plasma membrane and stimulate biliary bile acid secretion in vitro, we studied the effect of glucagon on taurocholate uptake and its relationship to plasma membrane potential in isolated rat hepatocytes. [14C]Taurocholate uptake was linear through 1 min and contained a saturable sodium‐dependent and a nonsaturable sodium‐independent component, Km of taurocholate uptake by the sodium‐dependent system was 18.4 μM.

1 September 1986

William A. Shaver, Harshika Bhatt, Burton Combes – 1 September 1986 – Low values for serum alkaline phosphatase activity were observed early in the course of two patients with Wilson's disease presenting with the combination of severe liver disease and Coombs' negative acute hemolytic anemia.

Javier Ariza, Francisco Gudiol, Carlos Dolz, Javier Xiol, Josefina Liñares, Jorge Bosch, Roman Pallares – 1 September 1986 – To determine the efficacy of aztreonam in the treatment of spontaneous bacterial peritonitis in patients with hepatic cirrhosis, 14 patients (7 males, 7 females) with 16 Gram‐negative infective episodes (12 Escherichia coli and 4 Klebsiella pneumoniae) were treated with aztreonam infusions at doses of 1 gm per 8 hr for a planned 14‐day period. Ages ranged from 40 to 75 years with a mean of 57 ± 10 years.

Haruya Meren, France Varin, Mary Ruwart, Ronald G. Thurman – 1 September 1986 – Previous work demonstrated that collagen deposition in the liver of rats fed a nutritionally deficient diet for 3 to 4 months was diminished markedly by 16,16‐dimethyl prostaglandin E2 treatment. In this study, rats were fed a high‐fat diet or a high‐fat diet deficient in lipotropes for 2 to 4 weeks prior to liver perfusion. Rates of O2 uptake by the liver were not changed by dietary manipulation.

Jose Chianale, Caroline Dvorak, Maryann May, Jorge J. Gumucio – 1 September 1986 – Within the hepatic acinus, the functional unit of liver parenchyma, the induction of cytochrome P‐450 protein by phenobarbital is manifested primarily in hepatocytes located closer to the hepatic venule, i.e., distal hepatocytes.

Hidekazu Tsukamoto, Sally J. Towner, Lefran M. Clofalo, Samuel W. French – 1 September 1986 – Severe hepatic steatosis and focal necrosis of hepatocytes have previously been induced in rats by continuous intragastric infusion of ethanol and a diet containing only 5% fat as a per cent of total calories as reported by us previously.

Zsuzsa Schaff, Jay H. Hoofnagle, Philip M. Grimley – 1 September 1986 – Two types of cytomembranous abnormalities were identified for the first time in liver biopsies from patients with chronic active type B hepatitis during treatment with recombinant α‐interferon. Tubuloreticular inclusions were present in the hepatic endothelial cells, Kupffer cells and perisinusoidal cells of liver biopsies from both patients, and they were absent in liver biopsies obtained before treatment.