Y. Peled, Z. Halpern, R. Baruch, G. Goldman, T. Gilat – 1 July 1988 – This study was performed to determine whether biliary cholesterol nucleates primarily from vesicles or micelles. Twenty gallbladder biles and 12 hepatic biles from patients with gallstones as well as 16 model biles were examined. The nucleation times (days) of the biles as well as their isolated vesicular and micellar fractions were determined and their lipid composition was analyzed. In 41 of 46 comparisons, cholesterol nucleated faster from vesicles than micelles; in only one case was the opposite found.

Willis C. Maddrey, David H. Van Thiel – 1 July 1988

David Y. Graham – 1 July 1988

1 July 1988

Yoram Bujanover, Sergio Amarri, Emanuel Lebenthal, James K. Petell – 1 July 1988 – The regulation of different maturational processes in the liver is believed to be influenced by the hormonal system. The aim of this study was to investigate the effect of two hormones, glucagon and dexamethasone, on levels of plasma membrane proteins in rat liver cells during late fetal and early postnatal stages of development.

Gilbert Reibnegger, Ingeborg Auhuber, Dietmar Fuchs, Arno Hausen, Gert Judmaier, Christian Prior, Ernst R. Werner, Helmut Wachter – 1 July 1988 – Elevated neopterin levels in blood or urine have been shown to be a marker for the activation of cell‐mediated immunity in vitro and in vivo.

The Rome Group for Epidemiology and Prevention of Cholelithiasis (GREPCO) – 1 July 1988 – The epidemiological associations of gallstone disease were evaluated in a population of 2,325 civil servants (1,244 men and 1,081 women) in Rome, Italy, which was enrolled in a cross‐sectional survey on cholelithiasis. Participants were screened for the presence of gallstones by gallbladder ultrasonography, completed a questionnaire on family and personal history and underwent a physical examination and blood chemistry.

Russell H. Wiesner, Patricia Grambsch, Nicholas F. Larusso, E. Rolland Dickson – 1 July 1988 – The clinicopathologic features and natural history of primary sclerosing cholangitis were reviewed in 53 patients followed at the Yale Liver Center during the past 30 yr. At presentation, the mean age of patients was 46 yr, and the male to female ratio was 1.4:1. Biliary sclerosis was limited to the intrahepatic ductal system in 21% of the patients.

Margo A. Denke, Scott M. Grundy – 1 July 1988 – Bile acid binding resins are indicated for treatment of elevated plasma low‐density lipoprotein cholesterol concentrations. In normoglyceridemic patients, plasma concentrations of low‐density lipoprotein cholesterol and total cholesterol are closely linked, and for this reason resin treatment of elevated total cholesterol levels in these patients is rational and warranted. Hypertriglyceridemic patients may also have elevated total cholesterol concentrations, and several such patients have been treated with resin.

Herbert L. Bonkovsky – 1 July 1988