R. Esteban, M. Buti, M. Vallés, H. Allende, J. Guardia, Gabriel Garcia, William S. Robinson, Peter B. Gregory, Thomas C. Merigan – 1 July 1986

Kevin D. Mullen, Scott C. Denne, Arthur J. McCullough, Samuel M. Savin, Deborah Bruno, Anthony S. Tavill, Satish C. Kalhan – 1 July 1986 – Alterations in protein and amino acid metabolism have been postulated to explain the frequent observations of muscle wasting and decreased plasma branched‐chain amino acid concentrations in cirrhosis.

Brian K. Singletary, David H. van Thiel, Patricia K. Eagon – 1 July 1986 – Gallbladder disease is more prevalent in women than men. Estrogen therapy has been associated with an increased incidence of gallbladder disease in both sexes. Further, increased progesterone levels have been implicated in impairment of gallbladder motility in pregnancy. Because sex hormones often exert their action through specific receptors, we investigated whether human gallbladder contains receptors for estrogen and progesterone.

Sohrab Mobarhan, Thomas J. Layden, Howard Friedman, Annette Kunigk, Philip Donahue – 1 July 1986 – This study was designed to determine whether chronic moderate ethanol ingestion alters the levels of vitamin A of liver and esophageal epithelium and if this is dependent on zinc nutriture. Forty male Sprague‐Dawley 4‐week‐old rats were divided into five groups: zinc‐deficient (0.9 ppm), ethanol‐fed; zinc‐deficient; zinc‐adequate (25 ppm); zinc‐adequate (25 ppm), ethanol‐fed; and zinc‐supplemented (50 ppm), ethanol‐fed.

Bertrand Nalpas, Anne Vassault, Serge Charpin, Bernard Lacour, Pierre Berthelot – 1 July 1986 – Serum mitochondrial aspartate aminotransferase activity was measured using an immunochemical method in 251 subjects, of whom 140 were chronic alcoholics. The alcoholic patients included 37 with normal liver routine tests (Group I), 61 with noncirrhotic alcoholic liver disease (Group II) and 42 with cirrhosis (Group III), of whom 21 had been abstainers for at least 2 months.

Peter F. Malet, Catherine L. Locke, Bruce W. Trotman, Roger D. Soloway – 1 July 1986 – The purpose of this study was to examine the role of calcium ions in gallbladder glycoprotein secretion in cultured guinea pig gallbladder explants. The calcium ionophore A23187 showed a threshold of 2 μg per ml medium for stimulation of secretion of [3H]glucosamine‐labeled glycoproteins over a 30 min incubation period. The ionophore at 3 and 5 μg per ml medium resulted in a 3‐ to 4‐fold increase in secretion of [3H]glucosamine‐labeled glycoproteins.

Tadashi Nishimura, Yukuo Yoshida, Fusao Watanabe, Masato Koseki, Toshiro Nishida, Kunio Tagawa, Yasunaru Kawashima – 1 July 1986 – To assess the severity of ischemic liver injury, we examined release of mitochondrial aspartate aminotransferase (EC 2.6.1.1) and its cytoplasmic isozyme from the ischemic rat liver into the circulation.

Sugantha Govindarajan, Kevin M. de Cock, Allan G. Redeker – 1 July 1986 – We evaluated the natural course of delta superinfection in patients with chronic B viral hepatitis by examining serial liver biopsy specimens from 23 patients. The mean follow‐up period was 2.5 years, and the average number of liver biopsies per patient was 2.8.

H. Terry Wepsic – 1 July 1986

Peter van der Sluijs, Hans P. Bootsma, Bart Postema, Frits Moolenaar, Dirk K. F. Meijer – 1 July 1986 – The isolated perfused rat liver preparation was employed to study hepatic disposition of the model drugcarrier conjugate fluorescein‐lactosylated albumin (F‐LnHSA) with special reference to the influence of the organic anion fluorescein on liver cell specificity of the endocytosed neoglycoprotein. Hepatic clearance of fluoresceinated neoglycoproteins was significantly faster than clearance of radioiodinated neoglycoproteins.