Neil D. Smith, James L. Boyer – 1 July 1986

J. Jaime Vazquez – 1 July 1986 – Two cases of disulfiram‐induced hepatitis are presented. Both cases had prompt recurrence of abnormal liver function tests after rechallenge with small doses of the drug. All cases of disulfiram‐induced hepatotoxicity reported in the English literature are reviewed.

R. E. Kirsch, N. M. Bass – 1 July 1986 – Rat liver glutathione S‐transferases have been purified to apparent electrophoretic homogeneity by S‐hexylglutathione‐linked Sepharose 6B affinity chromatography and CM‐cellulose column chromatography. At least 11 transferase activity peaks can be resolved including five Yb size homodimeric isozymes, two Yc size homodimeric isozymes, one Ya homodimeric isozyme, one Yα homodimeric isozyme, and two Ya‐Yc heterodimeric isozymes.

1 July 1986

Jurgen Ludwig, Robert L. Maccarty, Nicholas F. Larusso, Ruud A. F. Krom, Russell H. Wiesner – 1 July 1986 – We studied intrahepatic bile ducts of five patients with chronic ulcerative colitis and primary sclerosing cholangitis. The livers had been obtained at the time of orthotopic liver transplantation. After specimen cholangiography and perfusion fixation, sequential blocks and sections from portal tracts were studied, combining light microscopy with scanning electron microscopy. In vivo cholangiograms were studied also.

David Westaby, Walter Melia, John Hegarty, Alexander E. S. Gimson, Anthony J. Stellon, Roger Williams – 1 July 1986 – In a prospective, randomized controlled trial, 53 patients with variceal hemorrhage from portal hypertension, including 44 with cirrhosis, were allocated, after initial control of the bleeding, to treatment by sclerotherapy alone, or by this together with oral propranolol in a dose sufficient to reduce resting pulse rate by 25% during the period up to the time when varices were obliterated.

José A. Solis‐Herruzo, José V. Vidal, Francisco Colina, Fermin Santalla, Gregorio Castellano – 1 July 1986 – Nodular regenerative hyperplasia of the liver developed in five patients who had the toxic oil syndrome caused by ingestion of adulterated cooking oil. This hepatic complication was detected from 19 to 37 months (mean‐2.5 years) after the onset of the toxic oil syndrome. Nodular regenerative hyperplasia was asymptomatic, although all patients had persistently abnormal liver function.

Peter van der Sluijs, Hans P. Bootsma, Bart Postema, Frits Moolenaar, Dirk K. F. Meijer – 1 July 1986 – The isolated perfused rat liver preparation was employed to study hepatic disposition of the model drugcarrier conjugate fluorescein‐lactosylated albumin (F‐LnHSA) with special reference to the influence of the organic anion fluorescein on liver cell specificity of the endocytosed neoglycoprotein. Hepatic clearance of fluoresceinated neoglycoproteins was significantly faster than clearance of radioiodinated neoglycoproteins.

H. Terry Wepsic – 1 July 1986

Sugantha Govindarajan, Kevin M. de Cock, Allan G. Redeker – 1 July 1986 – We evaluated the natural course of delta superinfection in patients with chronic B viral hepatitis by examining serial liver biopsy specimens from 23 patients. The mean follow‐up period was 2.5 years, and the average number of liver biopsies per patient was 2.8.