Isosorbide dinitrate in experimental portal hypertension: A study of factors that modulate the hemodynamic response

Andres T. Blei, Jeanne Gottstein – 1 January 1986 – Isosorbide dinitrate, a long‐acting vasodilator, has been tested in human portal hypertension with conflictingresults. In order to determine some of the factors that could affect the individual response to this drug, we infused isosorbide dinitrate at a low dose (10 to 25 μg per kg per min) and a high dose (100 μg per kg per min) to rats with portal vein stenosis.

Reticuloendothelial system Fc receptor‐mediated clearance of IgG‐tagged erythrocytes from the circulation of patients with idiopathic ulcerative colitis and chronic liver disease

Gerald Y. Minuk, Noel B. Hershfield, Weng Y. Lee, Keith L. Maccannell, Roy Preshaw, Lorne M. Price, Eldon A. Shaffer, Lloyd R. Sutherland – 1 January 1986 – Immune complexes may be important in the pathogenesis of the liver disease associated with idiopathic ulcerative colitis.

Prognostic significance of serum bile acids in cirrhosis

Gerd A. Mannes, M.D., Christian Thieme, Frans Stellaard, Tiancai Wang, Tilman Sauerbruch, Gustav Paumgartner – 1 January 1986 – The value of serum bile acid concentrations for predicting prognosis in cirrhotics was compared with the prognostic significance of clinical and laboratory findings in a prospective 1‐year study of 76 patients with cirrhosis. A commercial radioimmunoassay for total serum‐conjugated primary bile acids was used. Of 76 patients, 16 died within the follow‐up period.

Liver biopsy immunotyping to characterize lymphoid malignancies

Christopher J. Verdi, Thomas M. Grogan, Robert Protell, Lynne Richter, Catherine Rangel – 1 January 1986 – To determine the feasibility of liver biopsy immunotyping to characterize hepatic lymphoid malignancies, we employed a panel of monoclonal antibodies on snapfrozen hepatic tissue from 18 patients. Six patients proved to have a histologic diagnosis of lymphoid malignancy. By using free avidin and biotin‐blocking reagents to block endogenous biotin, followed by standard immunochemistry, immunotyping was successful in all six cases.

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