Elisha Atkins – 1 July 1988

Cesare Cravetto, Gianpaolo Molino, Alan F. Hofmann, Gustavo Belforte, Basilio Bona – 1 July 1988 – The effect of three isolated defects in the enterohepatic circulation of bile acids on the size and distribution of the bile acid pool, plasma bile acid levels and bile acid secretion into the intestine was simulated using a linear multicompartmental physiological pharmacokinetic model previously used to simulate these aspects of bile acid metabolism in healthy man.

Esteban Mezey, Joseph E. Oesterling, James J. Potter – 1 July 1988 – The effect of a reduction in androgens on ethanol elimination was determined in man. Bilateral therapeutic orchiectomy in nine patients for prostatic carcinoma decreased mean plasma testosterone levels from 489.8 ± 31.2 (S.E.) ng per dl to 55.3 ± 3.8 ng per dl and resulted in an increase in the rate of ethanol elimination in seven patients, no change in one, and a decrease in one. The mean rate of ethanol elimination for all nine patients increased from 83.6 ± 4.0 to 100.4 ± 4.2 mg per kg body weight per hr (p < 0.02).

Yasushi Shiratori, Tateo Kawase, Shuichiro Shiina, Ken'Ichi Okano, Tsuneaki Sugimoto, Hitoshi Teraoka, Sunao Matano, Kazunori Matsumoto, Kazuo Kamii – 1 July 1988 – In an attempt to elucidate the role of hepatic macrophages in liver injury, we investigated galactosamine‐treated rats (500 mg per kg body weight). The rats received an i.v. injection of latex particles (2 × 109 particles per animal) prior to (latex‐galactosamine) or 12 to 16 hr subsequent to the galactosamine treatment (galactosamine‐latex).

Miquel Navasa, Jaime Bosch, Jürg Reichen, Conxita Bru, Ricardo Mastai, Thomas Zysset, Guillermo Silva, Jaime Chesta, Joan Rodés – 1 July 1988 – The effects of verapamil on hepatic and systemic hemodynamics and on liver function were investigated in 10 patients with portal hypertension due to advanced micronodular cirrhosis to verify whether, as it has been suggested, this calcium channel blocker may improve liver function and reduce portal pressure in these patients.

Ann A. Jerkins, Robert D. Steele – 1 July 1988 – In a series of experiments, rats were subjected to end‐to‐side portacaval shunts using either suture or nonsuture surgical procedures. Rats were maintained on cereal‐based or purified diets in pellet form. All rats recovered preoperative body weights within the experimental periods; however, recovery of preoperative body weight was influenced by surgical technique and diet composition.

Douglas M. Heuman, Z. Reno Vlahcevic, Marsha L. Bailey, Phillip B. Hylemon – 1 July 1988 – Bile acid synthesis is believed to be regulated by bile salts returning to the liver via the portal vein and suppressing cholesterol 7α‐hydroxylase, the rate‐limiting enzyme in the bile acid biosynthesis pathway. In order to characterize the relative effectiveness of bile salts in regulating bile acid synthesis, seven different bile acids were administered (1% w/w in chow) to rats over a 14‐day period.

Michael Phillips, Laurence M. Cummins – 1 May 1988 – Recent studies have demonstrated that commercial preparations of hepatitis B immune globulin often contain antibody to the human immunodeficiency virus. The presence of this antibody has aroused concerns that treatment with hepatitis B immune globulin might passively induce human immunodeficiency virus antibody seropositivity, leading to incorrect diagnoses of human immunodeficiency virus exposure.

Min Chan Lai, Myron J. Tong, Marek J. Nowicki, Shou‐Dong Lee – 1 May 1988 – Seventy HBsAg‐positive patients, including 24 with primary hepatocellular carcinoma, 34 with chronic active hepatitis, 12 with chronic persistent hepatitis and 30 asymptomatic healthy hepatitis B virus carriers were tested for anti‐HBc IgM using the Corzyme‐M test. Anti‐HBc IgM was detected in 50% of the primary hepatocellular carcinoma patients, 26.5% of the chronic active hepatitis patients, 25% of the chronic persistent hepatitis patients, but in none of the healthy hepatitis B virus carriers.

Jen‐Yang Chen, Tim J. Harrison, Chue‐Shue Lee, Ding‐Shinn Chen, Arie J. Zuckerman – 1 May 1988 – We have previously reported an analysis of DNA extracted from 31 primary liver tumors where, in 25 cases, we found chromosomal integration of hepatitis B virus DNA sequences. We describe here an investigation of the extent of the viral genome at each integration site in 15 of the hepatitis B virus DNA‐positive tumors using subgenomic fragments of the viral genome as probes.