Arnold N. Cohen, Jaime Kapitulnik, J. Donald Ostrow, Cecile C. Webster – 1 May 1986 – 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin, a potent inducer of microsomal cytochrome P448‐dependent monoxygenases, and phototherapy both accelerate bilirubin metabolism and decrease jaundice in Gunn rats. The effects of combined treatment with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin and light were studied in these rats by applying phototherapy for 65 hr, beginning 5 days after induction with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin.

Mohamed El Mouelhi, Frederick C. Kauffman – 1 May 1986 – Activities of glucuronosyltransferase, sulfotransferase, glutathione S‐transferase, β‐glucuronidase and sulfatase were determined in microdissected samples of periportal and pericentral sublobular regions from four human livers obtained at immediate autopsy. New methods are presented for the microdetermination of sulfotransferase and sulfatase activities in microdissected samples weighing 0.1 to 4 μg dry weight using umbelliferone and 4‐methylumbelliferone sulfate as substrates.

Hiroaki Okamoto, Sadakazu Usuda, Mitsunobu Imai, Katsumi Tachibana, Eiji Tanaka, Tomoko Kumakura, Masako Itabashi, Emiko Takai, Fumio Tsuda, Tetsuo Nakamura, Yuzo Miyakawa, Makoto Mayumi – 1 May 1986 – The antibody against the receptor for polymerized human serum albumin was determined by radioimmunoassay. The method involved the inhibition by the test serum, absorbed with HBsAg particles without the receptor, on the binding of polymerized human serum albumin to HBsAg particles with the receptor fixed on a solid support.

H. Reider, G. Ramadori, K.‐H. Meyer zum Büschenfelde, Bruce A. Runyon – 1 May 1986

Kunio Okuda – 1 May 1986

Richard J. Stenger – 1 May 1986 – During a one month period liver biopsy was carried out on eight patients with established acquired immune deficiency syndrome (AIDS) and two suspected of having AIDS to evaluate raised liver enzymes or unexplained fever and weight loss. Each of the 10 patients was found to have hepatic granulomas. Appropriate staining techniques showed acid‐fast bacilli in seven of the liver specimens. One specimen contained numerous Cryptococcal organisms. Two biopsies showed granulomas but no organisms.

Bernard F. Smith, J. Thomas LaMont – 1 May 1986

Shin Ohnishi, Tohru Murakami, Takashi Moriyama, Keiji Mitamura, Michio Imawari – 1 May 1986 – Both androgen and estrogen receptors were studied in human hepatocellular carcinoma and noncancerous liver tissue surrounding it. Androgen receptor was detected in the cytosol and/or nucleosol of 4 of 8 cancerous tissues and 1 of 6 noncancerous tissues. The levels of androgen receptor in hepatocellular carcinomas ranged from 3.4 to 37.6 fmoles per mg protein with dissociation constants (Kd) of 0.226 − 51.3×10−9M.

Andrew Stolz, Yuichi Sugiyama, John Kuhlenkamp, Bruce Osadchey, Tadataka Yamada, William Belknap, William Balistreri, Neil Kaplowitz – 1 May 1986 – Rat liver efficiently extracts bile acids from the portal blood and rapidly excretes them into bile. Little is known about the process by which bile acids traverse the liver cell from the sinusoidal to the canalicular membrane. In order to begin to define this process, we recently identified a pair of similar monomeric (33 kilodalton) cytosolic bile acid binding proteins (bile acid binders I and II, J. Biol. Chem.

Bruce A. Runyon, Dennis E. Van Epps – 1 May 1986 – Serial ascitic fluid samples were obtained during diuresis in seven patients with portal hypertension‐related ascites. The samples were tested for concentrations of total protein, CH100, C3 and C4 as well as for in vitro opsonic activity. These parameters were all found to increase to a statistically significant degree when the initial specimen was compared to the final specimen: total protein=1.5 vs. 2.7 gm per dl; CH100=9.3 vs. 20.2 units per ml; C3=13.4 vs. 23.8 mg per dl; C4=1.9 vs. 3.6 mg per dl, and opsonic activity=0.8 vs.