Mario Chojkier, Kip D. Lyche, Michael Filip – 1 July 1988 – We have shown, using the proline:ornithine dual label method, that in normal rats, hepatocytes contribute in vivo about 80 to 90% of the newly synthesized hepatic collagen. In order to quantify the contribution of hepatocytes and nonparenchymal cells to collagen synthesis in vivo in hepatic fibrogenesis, rats with CCl4‐induced liver fibrosis were given [53H]proline and [14C]ornithine intraperitoneally.

Laurence J. Wood, Denise Massie, Allan J. McLean, Francis J. Dudley – 1 July 1988 – Renal sodium handling, assessed by the response to acute saline loading, was investigated in 14 well‐compensated, nonascitic alcoholic cirrhotics and six normal controls. Urinary sodium excretion in cirrhotic patients (199 ± 141 μmoles per min) was significantly lower than in controls (387 ± 104 μmoles per min; p < 0.01) at 3 hr postinfusion. In contrast to controls, renal plasma flow and glomerular filtration rate did not increase in the cirrhotics in response to acute saline loading.

Bruce W. Trotman, C. Rajagopalan Nair, Seldon E. Bernstein – 1 July 1988 – The role of bilirubin conjugates in the formation of pigment gallstones is not known. In this study, we completely solubilized and then analyzed by high‐performance liquid chromatography specimens of black pigment gallstones from eight nb/nb mice with hereditary hemolytic anemia. Each dried gallstone specimen of about 200 μg was dissolved in 5 ml of dimethyl sulfoxide/0.15 M HCl/50 mM disodium‐EDTA (8:1:1 by volume) at room temperature.

Paul C. Adams, Lawrie W. Powell, June W. Halliday – 1 July 1988 – A human hepatic ferritin receptor has been isolated from human liver and has been purified using affinity chromatography. An affinity constant of 6.0 × 108 moles−1 liter was determined for the ferritin receptor. The molecular weight was estimated to be approximately 53,000 by gel electrophoresis. Binding of ferritin to the receptor coupled to a microparticulate support was specific for human liver ferritin with no binding of rat or porcine ferritin.

Miren Zuriñe Ibarra, Ignacio Mora, Juan Antonio Quiroga, Javier Bartolomé, Faustino La Banda, Juan Carlos Porres, Vicente Carreño – 1 July 1988 – Antibody directed against HBsAg carries idiotypic determinants that may induce an autoantiidiotype antibody response. We describe a solid‐phase radioimmunoassay which allows specific detection of either IgG or IgM antibody to antibody directed against HBsAg. Among 138 chronic hepatitis B virus carriers, IgG autoantiidiotype was detected in 98 (71%) and IgM autoantiidiotype in 110 (80%).

Jaime Bosch, Josep M. Bordas, Ricardo Mastai, David Kravetz, Miquel Navasa, Jaime Chesta, M. Pilar Pizcueta, Juan C. García‐Pagán, Joan Rodés – 1 July 1988 – The present study investigated to what extent measurements of wedged and free hepatic venous pressures adequately reflect the effects of vasopressin at the esophageal varices in patients with cirrhosis.

Thierry Poynard, Jean‐Pierre Pignon, Sylvie Naveau, Jean‐Claude Chaput, Claire Infante‐Rivard, Jean‐Pierre Villeneuve – 1 July 1988

M. Sawkat Anwer, Kathleen Nolan – 1 July 1988 – A pH‐stat method was used to characterize H+ efflux pathways in hepatocytes in order to determine if Na+/ H+ and Ca++/H+ exchange are involved in H+ efflux from hepatocytes under basal conditions and if cyclic AMP analogs affect Na+/H+ exchange. Total H+ efflux of freshly prepared hepatocytes ranged from 10 to 15 nmoles per min per mg protein. A part of total H+ efflux (35 to 50%) was dependent on extracellular Na+.

Agesilao D'Arienzo, Luigi Celentano, Alessandro Scuotto, Pasqualina Di Siervi, Vinicio Lombardi, Giovanni Squame, Gabriele Mazzacca – 1 July 1988 – In normal subjects, thallium‐201, administered per rectum, is taken up mainly by the liver (heart/liver ratio in normal subjects: 0.04 to 0.12). It has been claimed that an increased heart/liver ratio is suggestive of portal‐caval shunting and portal hypertension.

Luigi Accatino, Patricia Gavilan – 1 July 1988 – Phospholipids and bile acids, by virtue of their amphiphilic properties, can interact in nonpolar media forming “inverted” structures (micelles) which presumably have an hydrophilic core and might act as diffusional carriers (ionophores) of electrolytes across low dielectric constant media or lipid membranes.