Shizuko Takahashi, Edwin Simpser – 1 May 1981 – Mice infected with Schistosoma mansoni represent a model for study of hepatic fibrosis in humans. Production of trypsin‐activatable inactive collagenase and EDTA‐sensitive neutral protease was measured in the culture medium in which granuloma explants or primary cultures were maintained. Collagenase production was maximal in granulomas obtained from liver of mice 8 weeks postinfection and was inhibited by Actinomycin D or cycloheximide, and enhanced by lymphocyte factor(s) or heparin.

Darrell Doyle, Anh V. Le – 1 March 1981

Hans Popper, James W.‐K. Shih, John L. Gerin, Doris C. Wong, Bill H. Hoyer, William T. London, David L. Sly, Robert H. Purcell – 1 March 1981 – The livers of 33 captive woodchucks were examined histologically in 30 biopsy and 10 autopsy specimens and the findings were correlated with serum determinations for woodchuck hepatitis virus (WHV), surface antigen (WHsAg) and antibody (anti‐WHs), and WHV DNA and DNA polymerase.

Ferruccio Bonino, Bill Hoyer, Eugenie Ford, J. Wai‐Kuo Shih, Robert H. Purcell, John L. Gerin – 1 March 1981 – The hepatitis B virus‐associated delta antigen was detected in the serum of a young female drug addict with acute hepatitis and a previous history of hepatitis B surface antigen carrier. Delta antigen was associated with a 35‐ to 37‐nm subpopulation of hepatitis B surface antigen particles which banded at a density of 1.25 gm per cm3 of CsCl and contained a small RNA of approximately 5.5 × 105 molecular weight.

Z. Reno Vlahcevic, Marc Goldman, Charles C. Schwartz, Jan Gustafsson, Leon Swell – 1 March 1981 – The present report has been directed toward providing additional information on the major defects in the bile acid pathways present in patients with cirrhosis and its relevance to the problem of how bile acid synthesis is regulated in man. An unusual patient with severe liver disease and a completely broken enterohepatic circuit was studied. The synthesis of cholic and chenodeoxycholic acids was examined over a 5‐d period.

H. O. Conn, R. H. Resnick, N. D. Grace, C. E. Atterbury, D. Horst, R. J. Groszmann, P. Gazmuri, R. J. Gusberg, B. Thayer, D. Berk, S. C. Wright, R. Vollman, D. M. Tilson, W. V. McDermott, J. A. Cohen, M. Kerstein, A. L. Toole, J. P. Maselli, S. Razvi, A. Ishihara, H. Stern, C. Trey, E. T. O'hara, W. Widrich, H. Aisenberg, H. C. Stansel, M.

Norman W. Haines, Alfred L. Baker, James L. Boyer, Seymour Glagov, Harvey Schneir, Jonathan Jaspan, Donald J. Ferguson – 1 March 1981 – To evaluate factors predisposing to liver injury following jejunoileal bypass, 27 patients underwent clinical evaluation and liver biopsy prior to bypass and at 3, 6, 12, 18, and 24 months and yearly thereafter.

Mark L. Bassett, June W. Halliday, Lawrie W. Powell – 1 March 1981 – In a study of 20 families with idiopathic hemochromatosis, relatives of probands were classified as either homozygous, heterozygous, or normal according to their HLA phenotype. An abnormality in the serum iron concentration, total iron‐binding capacity, or serum ferritin concentration was present in all homozygotes and in 25% of heterozygotes. In heterozygotes, the mean total iron‐binding capacity was significantly decreased, and the mean hepatic iron concentration was significantly increased compared to normals.

Ulrich Gärtner, Richard J. Stockert, Anatol G. Morell, Allan W. Wolkoff – 1 March 1981 – The normal rat hepatocyte divides approximately once per year but, following two thirds hepatectomy, rapid cellular replication occurs throughout the remaining liver remnant. Using a multiple indicator dilution technique, single‐pass transport of 3H‐bilirubin and 125I‐asialoorosomucoid was studied in isolated perfused liver from 6hr to 6d after two thirds hepatectomy or sham surgery. Influx (k1), efflux (k2), and sequestration (k3) rates were quantitated by computer analysis.

Hideki Ohkubo, Kunio Okuda, Shinji Iida – 1 March 1981 – To elucidate the mechanism whereby corticosteroids decrease the serum bilirubin concentration, changes in bilirubin metabolism were studied in patients with Gilbert's syndrome using a bilirubin load test and/or nicotinic acid test before and after corticosteroid treatment. Steroid administration increased hepatic clearance and uptake of bilirubin; the transfer rate for biliary excretion was unaffected.