Stanley B. Benjamin, Kamal G. Ishak, Hyman J. Zimmerman, Amos Grushka – 1 May 1981 – Phenylbutazone has been reported to produce several forms of hepatic injury. A clinical and histologic review of 23 well‐substantiated cases in conjunction with review of 43 case reports in the literature was undertaken. Utilizing the histologic features and available clinical data, the injury was classified as moderate‐marked hepatocellular injury, minor hepatocellular injury, and other injury. No sexual differences were noted. Most patients had used the drug for less than 6 weeks.

Peter Kryger, Lars R. Mathiesen, Jan Aldershvile, Jens O. Nielsen, The Copenhagen Hepatitis Acuta Programme – 1 May 1981 – To evaluate the clinical implication of IgM antibody against hepatitis B core antigen (anti‐HBc IgM), a consecutive series of 87 patients with acute type B hepatitis and 16 healthy carriers of hepatitis B surface antigen (HBsAg) were studied by a newly developed reverse ELISA technique.

George H. Scullard, Ljudevit L. Andres, Harry B. Greenberg, Joseph L. Smith, Vinod K. Sawhney, E. Andrew Neal, Anmol S. Mahal, Hans Popper, Thomas C. Merigan, William S. Robinson, Peter B. Gregory – 1 May 1981 – Twelve of 32 patients lost HBeAg and DNA polymerase from their serum after completing antiviral therapy with interferon and/or adenine arabinoside. Three lost serum HBsAg as well. Loss of corresponding viral markers from hepatic tissue was also seen.

Patricia Ponce, Javier Cordero, Marcos Rojkind – 1 May 1981 – Adult rat hepatocytes efficiently attach to intact connective tissue fibers prepared from normal rat liver; this material has been given the name of “biomatrix”. The cells remain alive and differentiated for at least 4 months in culture. The liver biomatrix contains both collagen and noncollagenous glycoproteins. Heretofore, the functions of the different components of the biomatrix in facilitating cell adhesion and promoting survival and differentiation of rat hepatocytes have not been investigated.

Suzanne Lagarde, Elwyn Elias, James B. Wade, James L. Boyer – 1 May 1981 – Freeze fracture analyses of hepatocyte tight junctions reveal interconnecting strands which represent a semipermeable blood‐bile barrier. In epithelia, strand number can be correlated with transepithelial resistance and junctional permeability, but a functional relationship is not always seen. We have devised an analytical method to measure accurately strand number as well as junction depth over a large area of junction.

Hector Orrego, Yedy Israel, Laurence M. Blendis – 1 May 1981

Gerald F. Johnson, Anatol G. Morell, Richard J. Stockert, Irmin Sternlieb – 1 May 1981 – Hepatic copper overload inherited as an autosomal recessive trait in Bedlington Terriers is characterized by the presence of hepatocellular lysosomal granules of unusually high specific gravity and electron density which contain at least two thirds of the total hepatic copper.

1 May 1981

C. S. Davidson – 1 May 1981

Kazuaki Kamisaka, Hidenori Maezawa, Tooru Inagaki, Kenichi Okano – 1 May 1981 – Human Z protein from liver was purified to homogeneity. The protein has a molecular weight of 11,000 and an isoelectric point of pH 5.8. Circular dichroism spectra of Z protein‐bilirubin (uncon‐jugated and diglucuronide) complexes revealed two ellipticity extrema, a negative peak at 460 nm, and a positive peak at 410 nm. Human serum albumin had a higher affinity for bilirubin than did Z protein.