The mechanism of hepatic coma
Leslie Zieve – 1 July 1981
Muscle protein breakdown in liver cirrhosis and the role of altered carbohydrate metabolism
Giulio Marchesini, Marco Zoli, Angela Angiolini, Cristina Dondi, Francesco B. Bianchi, Emilio Pisi – 1 July 1981 – The rates of muscle protein breakdown, as estimated by the urinary excretion of 3‐methylhistidine, were assessed in 30 cirrhotics and 15 controls on a strictly controlled diet. 3‐Methylhistidine excretion was increased in cirrhotics irrespective of the etiology of the disease, and correlated with basal glucagon levels and with the insulin/glucagon ratio.
Making sense out of nonsense
Harold O. Conn – 1 July 1981
Hepatocyte bile secretion: Current views and controversies
Serge Erlinger – 1 July 1981
Hepatic and extrahepatic glucuronidation of lorazepam in the dog
John F. Gerkens, Paul V. Desmond, Steven Schenker, Robert A. Branch – 1 July 1981 – The pharmacokinetic disposition of lorazepam was investigated in sham‐operated anesthetized dogs, dogs with hepatic devascularization, and dogs with total splanchnic devascularization following i.v. administration of 0.3 mg per kg of the drug. In sham‐operated dogs, lorazepam distribution was extensive (100 ± 15.2 liters) and clearance approximated expected liver blood flow (971 ± 91 ml per min). Lorazepam glucuronide levels in plasma rose rapidly in the first hour and reached a plateau by 5 hr.
Masthead
1 July 1981
Plasma clearance of intravenous chenodeoxycholic acid in rabbits with varying severity of hepatocellular necrosis
Malcolm Mackinnon, Pauline Hall – 1 July 1981 – The plasma clearance of an i.v. bolus of chenodeoxycholic acid (10 μm per kg) was determined in rabbits with graded degrees of hepatocellular necrosis produced by i.p. injection of carbon tetrachloride. Plasma chenodeoxycholic acid levels were determined by radioimmunoassay, and the volume fraction of necrosis was quantitated by a computerized (Quantimet 720) system. Impaired plasma clearance was observed only when necrosis was extensive, and the volume fraction of necrosis >34%.
The effects of variation in dietary protein and ethanol on hepatic microsomal drug metabolism in the rat
Mack C. Mitchell, Esteban Mezey, Willis C. Maddrey – 1 July 1981 – The effects of chronic ethanol consumption and variations in dietary protein content on microsomal drug metabolism were studied in rats pair‐fed liquid diets containing 10, 20, or 30% dietary protein with or without ethanol. In vivo drug metabolism was measured by aminopyrine breath tests and aminopyrine blood elimination kinetics. In vitro drug metabolism was assessed by measuring aminopyrine N‐demethylase activity in the hepatic microsomal fraction.