Stewart Sell, Hyam L. Leffert – 1 January 1982 – Analysis of liver from rats exposed to chemical hepatocarcinogens has led to a model that postulates sequential premalignant changes, culminating in hepatoma formation from neoplastic nodules. Several experimental protocols devised during the last quarter century have focused upon this lineage model. But proof that neoplastic nodules are the definitive premalignant lesions has not been achieved.

Karen L. Lindsay, Allan G. Redeker, Mary Ashcavai – 1 November 1981 – Seven patients are described in whom HBsAg persisted for 13 to 98 months after acute viral hepatitis B and then became nondetectable. All patients subsequently developed anti‐HBs. During the period of HBs‐antigenemia, liver biopsies in five patients showed persistent viral hepatitis. Retrospectively, impending negativity of HBsAg was predictable in five patients by a decrease in HBsAg titer, and in four patients by persistent normalization of serum alanine aminotransferase.

Gary C. Kanel, Toshikazu Uchida, Robert L. Peters – 1 November 1981 – Hepatic amyloid, when identified, is usually located in the sinusoids, portal tracts, and arterioles. We report 14 cases of hepatic amyloidosis where eosinophilic globules having the histochemical and electron microscopic features of classic amyloid were found. The globules were round to oval, 5 to 40 μm in diameter, and were found within the space of Disse as well as aggregated within the portal tracts.

1 November 1981

1 November 1981

John K. Boitnott, Willis C. Maddrey – 1 November 1981 – Interrelationships among histologic features of alcoholic liver disease were studied in 24 chronic alcoholics who took part in a double‐blind, controlled trial of prednisolone vs. placebo therapy. Each patient underwent liver biopsy at the start and upon completion of the 1‐month study.

Mario Rizzetto, Maria G. Canese, Robert H. Purcell, William T. London, L. David Sly, John L. Gerin – 1 November 1981 – The occurrence and pathogenetic role of intrahepatic deposits of immunoglobulins in experimental viral infection have been evaluated by determining with immunofluorescence their capacity to fix complement in vitro [in vitro complement fixation (VCF)]. Liver biopsies from chimpanzees chronically or acutely infected with hepatitis B virus or the hepatitis B surface antigen (HBsAg)‐associated δ agent were used in the study.

Francine Marciano‐Cabral, Karen L. Rublee, Robert L. Carithers, Edward A. Galen, Thomas J. Sobieski, Guy A. Cabral – 1 November 1981 – Liver biopsies from five patients with chronic non‐A, non‐B (NANB) hepatitis were examined by electron microscopy for hepatocellular alterations. Circular fused membranes were observed within the cytoplasm of hepatocytes of four of the patients. Aggregates of intranuclear particles, measuring 22 ± 2 nm in diameter, were also seen in two of the biopsies in which fused membranes were identified.

Michael J. O'brien, Leonard S. Gottlieb – 1 November 1981

William M. Belknap, William F. Balistreri, Frederick J. Suchy, Philip C. Miller – 1 November 1981 – We have shown that serum bile acid concentrations are elevated in human infants reflecting physiologic immaturity of the enterohepatic circulation. To define further the ontogeny of bile acid metabolism in mammals, we examined maturational changes in the serum concentration of total cholate conjugates by radioimmunoassay in fetal, neonatal, suckling, and mature Sprague‐Dawley rats.