Chronic non‐A, non‐B hepatitis: Ultrastructural and serologic studies

Francine Marciano‐Cabral, Karen L. Rublee, Robert L. Carithers, Edward A. Galen, Thomas J. Sobieski, Guy A. Cabral – 1 November 1981 – Liver biopsies from five patients with chronic non‐A, non‐B (NANB) hepatitis were examined by electron microscopy for hepatocellular alterations. Circular fused membranes were observed within the cytoplasm of hepatocytes of four of the patients. Aggregates of intranuclear particles, measuring 22 ± 2 nm in diameter, were also seen in two of the biopsies in which fused membranes were identified.

Experimental HBV and δ infections of chimpanzees: Occurrence and significance of intrahepatic immune complexes of HBcAg and δ antigen

Mario Rizzetto, Maria G. Canese, Robert H. Purcell, William T. London, L. David Sly, John L. Gerin – 1 November 1981 – The occurrence and pathogenetic role of intrahepatic deposits of immunoglobulins in experimental viral infection have been evaluated by determining with immunofluorescence their capacity to fix complement in vitro [in vitro complement fixation (VCF)]. Liver biopsies from chimpanzees chronically or acutely infected with hepatitis B virus or the hepatitis B surface antigen (HBsAg)‐associated δ agent were used in the study.

Alcoholic liver disease: I. Interrelationships among histologic features and the histologic effects of prednisolone therapy

John K. Boitnott, Willis C. Maddrey – 1 November 1981 – Interrelationships among histologic features of alcoholic liver disease were studied in 24 chronic alcoholics who took part in a double‐blind, controlled trial of prednisolone vs. placebo therapy. Each patient underwent liver biopsy at the start and upon completion of the 1‐month study.

Globular hepatic amyloid–‐an unusual morphologic presentation

Gary C. Kanel, Toshikazu Uchida, Robert L. Peters – 1 November 1981 – Hepatic amyloid, when identified, is usually located in the sinusoids, portal tracts, and arterioles. We report 14 cases of hepatic amyloidosis where eosinophilic globules having the histochemical and electron microscopic features of classic amyloid were found. The globules were round to oval, 5 to 40 μm in diameter, and were found within the space of Disse as well as aggregated within the portal tracts.

Delayed HBsAg clearance in chronic hepatitis B viral infection

Karen L. Lindsay, Allan G. Redeker, Mary Ashcavai – 1 November 1981 – Seven patients are described in whom HBsAg persisted for 13 to 98 months after acute viral hepatitis B and then became nondetectable. All patients subsequently developed anti‐HBs. During the period of HBs‐antigenemia, liver biopsies in five patients showed persistent viral hepatitis. Retrospectively, impending negativity of HBsAg was predictable in five patients by a decrease in HBsAg titer, and in four patients by persistent normalization of serum alanine aminotransferase.

Membrane traffic at the hepatocyte's sinusoidal and canalicular surface domains

W. Howard Evans – 1 September 1981 – Traffic in the environs of regions of the hepatocyte's plasma membrane is heavy. A fuller understanding of the nature and control of this membrane traffic depends on the appreciation of the hepatocyte's plasma membrane. This conglomerate consists of a receptor‐rich and metabolically dynamic blood‐sinusoidal domain which is separated from the bile canalicular domain by a lateral domain which participates in cell‐cell interactions (1, 2).

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