Gerald M. Fleischner, Rachel Morecki, Takamasa Hanaichi, Hisao Hayashi, Nelson Quintana, Irmin Sternlieb – 1 September 1991 – A 56‐yr‐old woman with long‐standing rheumatoid arthritis exhibited jaundice, pruritus and abdominal discomfort after 8 yr of periodic gold sodium thiomalate injections amounting to a cumulative dose in excess of 2.5 gm. Histopathological examination of the liver biopsy specimen showed submassive loss of parenchyma, collapse of reticulin and mixed cellular inflammatory infiltrates.

Robert M. Merion, Darrell A. Campbell – 1 September 1991 – Surgical reduction of donor livers to treat small children has been performed successfully in several centers. While this procedure improves the allocation of livers, it does not increase the organ supply. We have extended reduced‐size orthotopic liver transplantation (OLT) to treat 18 patients with 9 livers, accounting for 26% of our transplants during a 10‐month period and have evaluated the results. In 18 split liver OLTs, patient survival was 67% and graft survival was 50%.

Abraham Zifroni, Raul C. Schiavi, Fenton Schaffner – 1 September 1991 – The effects of nonalcoholic liver disease on sexual desire, arousal, activity, orgasmic function and satisfaction and serum testosterone levels were studied in 75 men with nonalcoholic liver disease. Each man was interviewed about his sexual behavior and problems and was asked to comment on whether he felt liver disease affected his sexual function. The average age of the patients was 49 yr, and a wide variety of liver diseases was represented.

Rosemarie L. Fisher, Alan F. Hofmann, James L. Converse, Steven S. Rossi, Shu‐Ping Lan – 1 September 1991 – To test whether hepatotoxicity occurring in National Cooperative Gallstone Study patients was caused by a toxic effect of chenodiol per se or of lithocholate caused by defective sulfation, bile samples were analyzed using a new high‐performance liquid chromatography method that measures the proportions of the four individual lithocholate amidates (sulfated and unsulfated lithocholylglycine and lithocholyltaurine) and all common bile acid amidates.

1 September 1991

Fernando Corrales, Pilar Ochoa, Carmen Rivas, Manuel Martin‐Lomas, José M. Mato, Maria A. Pajares – 1 September 1991 – The hepatic levels of glutathione in rats treated with buthionine sulfoximine (4 mmol/kg), an inhibitor of glutathione synthesis, were 72.5% ± 4.9% of those determined in control animals. This decrease in glutathione concentration was prevented by the administration of glutathione monoethyl ester (7.5 mmol/kg). S‐Adenosyl‐L‐methionine‐synthetase activity in the liver of rats treated with buthionine sulfoximine was 39.4% ± 6.5% of that determined in control animals.

David H. Adams, Stefan G. Hubscher, Jean Shaw, Gerald D. Johnson, Christopher Babbs, Robert Rothlein, James M. Neuberger – 1 September 1991 – It has been suggested that immunological mechanisms involving lymphocyte‐mediated damage are important in the characteristic bile‐duct damage that occurs in primary biliary cirrhosis and primary sclerosing cholangitis.

Johnson Y. N. Lau, Vincent G. Bain, Susan E. Davies, Graeme J. M. Alexander, Roger Williams – 1 September 1991 – Serum and liver HBsAg bear an inverse relation to each other during the evolution of chronic hepatitis B virus infection and the quantity of HBsAg in tissue rises gradually with time. In this study, intracellular and extracellular levels of HBsAg were measured by radioimmunoassay in primary culture of hepatocytes from 30 patients with chronic hepatitis B virus infection to determine a possible relationship with hepatitis B virus replication.

Raymond S. Koff – 1 September 1991

Yoichi Kurebayashi, Yuko Honda – 1 September 1991 – 16,16‐Dimethyl prostaglandin E2, a known cytoprotective agent, was examined for its ability to protect the liver against complement‐mediated necrosis induced by an intravenous injection of a monoclonal antibody against a rat liver—specific antigen in rats.