J. Hilary Green, Peter N. Bramley, Monty S. Losowsky – 1 September 1991 – Wasting is common in end‐stage primary biliary cirrhosis and causes concern in patients facing liver transplantation. We have quantified resting metabolic rate and diet‐induced thermogenesis in seven patients with primary biliary cirrhosis, in seven patients after liver transplantation who had previously been diagnosed as having primary biliary cirrhosis and in seven controls.

Jean‐François Bretagne, Jean‐Luc Raoul, Michel Gosselin, Kunio Okuda, Kunio Kimura – 1 August 1991

Raymond S. Koff – 1 August 1991

John A. Hermos – 1 August 1991

Daniel W. Nebert – 1 August 1991 – These two reports describe recombinant DNA tests that can identify individuals having a defect in the cytochrome P450IID6 (CYP2D6)‐mediated oxidative metabolism of debrisoquine and more than two dozen other drugs that are commonly prescribed. The poor metabolizer (PM), representing 5% to 10% of the northern European white population is homozygous for an autosomal recessive trait. Compared with the extensive metabolizer (EM) phenotype, the PM individual is more prone to toxicity caused by some of these drugs.

Miriam J. Alter – 1 August 1991

Kim A. Sathre, Monica L.‐S. Tsang, James A. Weatherbee, Clifford J. Steer – 1 August 1991 – Cellular processing of 125I‐labeled transforming growth factor‐β1 was investigated in the human hepatoma cell lines Hep G2 and Hep 3B. Binding of 125I‐transforming growth factor‐β1 to cell surface receptors was specific, saturable and calciumindependent. Both cell lines exhibited a single class of high‐affinity (Kd = 2.2 × 10−10 mol/L) binding sites (4.5 × 103 for the Hep G2 cell; 1.5 × 103 for the Hep 3B cell) for both human and porcine transforming growth factor‐β1.

Yuka Akashi, Chizu Koreeda, Shigeki Enomoto, Shozo Uchiyama, Takako Mizuno, Yasuko Shiozaki, Yoshiko Sameshima, Kyoichi Inoue – 1 August 1991 – A multivariate analysis of data from 90 patients with unresectable hepatocellular carcinoma was performed using Cox's regression model to identify factors possibly affecting their prognoses. Thirty‐one patients underwent arterial anticancer chemotherapy, and the remaining 59 patients received transcatheter arterial embolization with anticancer agents.

Peter G. Langley, Rick Keays, Robin D. Hughes, Alastair Forbes, Ullrich Delvos, Roger Williams – 1 August 1991 – Previous studies have shown that antithrombin III levels are low in fulminant hepatic failure, and heparin kinetics are abnormal, making control of heparinization difficult during hemodialysis of these patients who are at risk of bleeding.

Flemming Bendtsen, Niels Juel Christensen, Thorkild I. A. Sørensen, Jens H. Henriksen – 1 August 1991 – Circulating catecholamines are increased in cirrhosis with portal hypertension, and increase further after propranolol. In 23 cirrhotic patients, plasma norepinephrine and epinephrine were determined in an artery, the azygos vein, the right renal vein and a hepatic vein before and after an oral 80‐mg dose of propranolol.