Carol R. Gardner, Arthur J. Wasserman, Debra L. Laskin – 1 August 1991 – Macrophage‐mediated cytotoxicity toward tumor cells usually involves extracellular lysis of the targets. In this study, we report that liver macrophages from rats treated with lipopolysaccharide (5 mg/kg, intravenous) also kill certain tumor cell targets by phagocytosis. Liver macrophages were coincubated with P815 mouse mastocytoma cells for 24 to 72 hr at an effector/target ratio of 10:1. Macrophage phagocytosis was characterized by flow cytometry and by light and electron microscopy.

Jeffrey D. Laskin, Anthea Dokidis, Carol R. Gardner, Debra L. Laskin – 1 August 1991 – Production of extracellular matrix proteins — in particular, the proteoglycans‐by macrophages is important in many of their functions, including cell‐cell recognition, adhesion and phagocytosis. In this study, we characterized changes in sulfated proteoglycan production by hepatic macrophages following in vivo activation with lipopolysaccharide. We found that both resident Kupffer cells and liver macrophages from lipopolysaccharide‐treated rats incorporated [35S]sulfate into proteoglycans.

Masayoshi Yamauchi, Hisato Nakajima, Mitsuru Ohata, Junnichi Hirakawa, Yuji Mizuhara, Masao Nakahara, Kazuo Kimura, Kiyoshi Fujisawa, Haruo Kameda – 1 August 1991 – Pooled sera collected from cirrhotic patients was fractionated by affinity chromatography with a fibronectin receptor monoclonal antibody against the β‐subunit of fibronectin receptor. Eluates were assayed using Western immunoblotting.

Angelo Gatta, Paolo Angeli, Lorenza Caregaro, Francesca Menon, David Sacerdoti, Carlo Merkel – 1 August 1991 – It has been hypothesized that the magnitude of proximal sodium reabsorption affects the response to aldosterone antagonists in nonazotemic cirrhotic patients with ascites. To verify this hypothesis, we evaluated intrarenal sodium handling by lithium clearance in 51 nonazotemic ascitic cirrhotic patients and in 23 controls who were maintained on the same low‐sodium diet (80 mmol/day).

Patrizia Pontisso, Alfredo Alberti, William P. J. Leenders, Sing‐Hiem Yap – 1 August 1991

Michael Houghton, Amy Weiner, Jang Han, George Kuo, Qui‐Lim Choo – 1 August 1991

H. Thomas Schneider, Martin Fromm, Roland Ott, Paul Janowitz, Werner Swobodnik, Horst Neuhaus, Christian Ell – 1 August 1991 – To compare the fragmentation efficiency of three different shockwave systems, 63 human gallstone triplets were disintegrated in vitro using an electrohydraulic (MPL 9000, Dornier), an electromagnetic (Lithostar Plus, Siemens) and a piezoelectric (Piezolith 2300, R. Wolf) lithotripter. Since each stone triplet was obtained from the same gallbladder, the concrements of one such set were identical in physicochemical parameters.

Amadlo Telenti, Thomas F. Smith, Jurgen Ludwig, Michael R. Keating, Rund A. F. Krom, Russell H. Wiesner – 1 August 1991 – Epstein‐Barr virus infection has been associated with a broad spectrum of clinical manifestations, depending on the immune status of the host. In this report, we describe two liver transplant patients who received hepatic allografts from donors serologically positive for Epstein‐Barr virus and who experienced primary infection with Epstein‐Barr virus associated with prolonged liver graft dysfunction.

Han‐Chieh Lin, Olivier Soubrane, Didier Lebrec – 1 August 1991 – The hemodynamic effects, including mesentericsystemic shunts of early chronic administration of clonidine, were studied in conscious, unrestrained, portal vein‐stenosed rats.

John Paul Roberts, Nancy L. Ascher, John Lake, Jan Capper, Sarla Purohit, Marvin Garovoy, Roy Lynch, Linda Ferrell, Teresa Wright – 1 August 1991 – Four cases of patients in whom graft vs. host disease developed after liver transplantation are described. The clinical course of each patient was similar with fever, pancytopenia, diarrhea and a skin rash developing 1 or 2 mo after liver transplantation. The clinical diagnosis was made from skin or colon biopsy specimens. Liver dysfunction did not occur in the patients at the time of diagnosis.