Kupffer cell prostaglandin‐E2 production is amplified during hepatic regeneration
Mark P. Callery, Martin J. Mangino, M. Wayne Flye – 1 August 1991 – Prostaglandin‐E2 increases in liver tissue after partial hepatectomy and stimulates DNA synthesis in primary cultures of hepatocytes. This study evaluated the capacity of Kupffer cells isolated at various intervals after partial hepatectomy to produce prostaglandin E2 in response to bacterial endotoxin. This stimulator of Kupffer cells is a normal endogenous component of portal venous blood.