Are patients with primary biliary cirrhosis hypermetabolic? a comparison between patients before and after liver transplantation and controls

J. Hilary Green, Peter N. Bramley, Monty S. Losowsky – 1 September 1991 – Wasting is common in end‐stage primary biliary cirrhosis and causes concern in patients facing liver transplantation. We have quantified resting metabolic rate and diet‐induced thermogenesis in seven patients with primary biliary cirrhosis, in seven patients after liver transplantation who had previously been diagnosed as having primary biliary cirrhosis and in seven controls.

Is intrapulmonary arteriovenous shunting and hypoxemia a contraindication for liver transplantation?

L. Siw Eriksson – 1 September 1991 – A 12‐year‐old boy with Wilson's disease developed exertional dyspnea, cyanosis, and finger clubbing 10 months after diagnosis. The hypoxemia was caused by arteriovenous shunting, demonstrated by radionuclide scanning and pulmonary arteriography. Orthotopic liver transplantation was performed after the development of severe hypoxemia. There was no apparent reversal of the intrapulmonary arteriovenous shunting and he died 10 days posttransplantation of multiple organ failure secondary to hypoxemia.

Systemic, splanchnic and renal hemodynamic effects of a dopaminergic dose of dopamine in patients with cirrhosis

Yannick Bacq, Christophe Gaudin, Antoine Hadengue, Dominique Roulot, Alain Braillon, Richard Moreau, Didier Lebrec – 1 September 1991 – The effects of dopamine on kidney function have not been elucidated in patients with cirrhosis. Moreover, although increased portal pressure has been observed with supradopaminergic doses of dopamine in these patients, the splanchnic hemodynamic effects of low doses of dopamine have not been previously studied.

Movement of IgM antibody from blood to bile in rats

Peter G. C. Hansen, Graham D. F. Jackson – 1 September 1991 – The movement from blood to bile of passively injected autologous IgM antibody against horse erythrocytes was studied in rats. Both native and neuraminidase‐treated antibody entered bile intact, with the peak titers for both measured between 60 and 90 min after injection. A small part (0.38%) of the injected dose of native antibody and 1.05% of the asialo‐IgM antibody appeared in bile over 24 hr. These recoveries represented only a small fraction of the activity, which apparently disappeared from serum over the period.

Protection by 16,16‐dimethyl prostaglandin E2 and dibutyryl cyclic AMP against complement‐mediated hepatic necrosis in rats

Yoichi Kurebayashi, Yuko Honda – 1 September 1991 – 16,16‐Dimethyl prostaglandin E2, a known cytoprotective agent, was examined for its ability to protect the liver against complement‐mediated necrosis induced by an intravenous injection of a monoclonal antibody against a rat liver—specific antigen in rats.

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