1 September 1991

Yannick Bacq, Christophe Gaudin, Antoine Hadengue, Dominique Roulot, Alain Braillon, Richard Moreau, Didier Lebrec – 1 September 1991 – The effects of dopamine on kidney function have not been elucidated in patients with cirrhosis. Moreover, although increased portal pressure has been observed with supradopaminergic doses of dopamine in these patients, the splanchnic hemodynamic effects of low doses of dopamine have not been previously studied.

Peter G. C. Hansen, Graham D. F. Jackson – 1 September 1991 – The movement from blood to bile of passively injected autologous IgM antibody against horse erythrocytes was studied in rats. Both native and neuraminidase‐treated antibody entered bile intact, with the peak titers for both measured between 60 and 90 min after injection. A small part (0.38%) of the injected dose of native antibody and 1.05% of the asialo‐IgM antibody appeared in bile over 24 hr. These recoveries represented only a small fraction of the activity, which apparently disappeared from serum over the period.

Yoichi Kurebayashi, Yuko Honda – 1 September 1991 – 16,16‐Dimethyl prostaglandin E2, a known cytoprotective agent, was examined for its ability to protect the liver against complement‐mediated necrosis induced by an intravenous injection of a monoclonal antibody against a rat liver—specific antigen in rats.

Raymond S. Koff – 1 September 1991

Johnson Y. N. Lau, Vincent G. Bain, Susan E. Davies, Graeme J. M. Alexander, Roger Williams – 1 September 1991 – Serum and liver HBsAg bear an inverse relation to each other during the evolution of chronic hepatitis B virus infection and the quantity of HBsAg in tissue rises gradually with time. In this study, intracellular and extracellular levels of HBsAg were measured by radioimmunoassay in primary culture of hepatocytes from 30 patients with chronic hepatitis B virus infection to determine a possible relationship with hepatitis B virus replication.

David H. Adams, Stefan G. Hubscher, Jean Shaw, Gerald D. Johnson, Christopher Babbs, Robert Rothlein, James M. Neuberger – 1 September 1991 – It has been suggested that immunological mechanisms involving lymphocyte‐mediated damage are important in the characteristic bile‐duct damage that occurs in primary biliary cirrhosis and primary sclerosing cholangitis.

Fernando Corrales, Pilar Ochoa, Carmen Rivas, Manuel Martin‐Lomas, José M. Mato, Maria A. Pajares – 1 September 1991 – The hepatic levels of glutathione in rats treated with buthionine sulfoximine (4 mmol/kg), an inhibitor of glutathione synthesis, were 72.5% ± 4.9% of those determined in control animals. This decrease in glutathione concentration was prevented by the administration of glutathione monoethyl ester (7.5 mmol/kg). S‐Adenosyl‐L‐methionine‐synthetase activity in the liver of rats treated with buthionine sulfoximine was 39.4% ± 6.5% of that determined in control animals.

1 September 1991

Rosemarie L. Fisher, Alan F. Hofmann, James L. Converse, Steven S. Rossi, Shu‐Ping Lan – 1 September 1991 – To test whether hepatotoxicity occurring in National Cooperative Gallstone Study patients was caused by a toxic effect of chenodiol per se or of lithocholate caused by defective sulfation, bile samples were analyzed using a new high‐performance liquid chromatography method that measures the proportions of the four individual lithocholate amidates (sulfated and unsulfated lithocholylglycine and lithocholyltaurine) and all common bile acid amidates.