Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: Their prevalence and clinical relevance

Charles L. Mendenhall, Leonard Seeff, Anna Mae Diehl, Saad J. Ghosn, Samuel W. French, Peter S. Gartside, Susan D. Rouster, Zelma Buskell‐Bales, Charles J. Grossman, Gary A. Roselle, Robert E. Weesner, Pedro Garcia‐Pont, Stephen J. Goldberg, Thomas W. Kiernan, Carlo H.

Use of conserved sequences from hepatitis C virus for the detection of viral RNA in infected sera by polymerase chain reaction

Genevieve Inchauspe, Kenji Abe, Suzanne Zebedee, Marc Nasoff, Alfred M. Prince – 1 October 1991 – Three oligonucleotide primer combinations selected from the 5′ noncoding, the nucleocapsid and the putative nonstructural regions of the hepatitis C virus genome were compared in a nested polymerase chain reaction assay with respect to sensitivity and specificity for the detection of viral RNA in chimpanzeeinfected and human‐infected sera.

Molecular forms and biological activity of atrial natriuretic factor in patients with cirrhosis and ascites

Wladimiro Jiménez, Jolanta Gutkowska, Pere Ginés, Vicente Arroyo, Francisca Rivera, Joan Rodés – 1 October 1991 – Patients with cirrhosis and ascites show sodium retention and normal or increased plasma levels of atrial natriuretic factor, a peptide with powerful natriuretic activity.

Intracranial pressure waves and intracranial hypertension in rats with ischemic fulminant hepatic failure

Stephen Webster, Jeanne Gottstein, Andres T. Blei, Robert Levy – 1 October 1991 – Brain edema and intracranial hypertension are a major cause of death in fulminant hepatic failure. We have shown that brain water measured in rats after hepatic devascularization (portacaval anastomosis followed in 24 to 48 hr by ligation of the hepatic artery) increases with the progression of encephalopathy. In this study, we examined whether intracranial hypertension develops in this model of fulminant hepatic failure.

Efflux of protons from acidic vesicles contributes to cytosolic acidification of hepatocytes during ATP depletion

Steven F. Bronk, Gregory J. Gores – 1 October 1991 – The objective of this study was to determine the relationship between cytosolic pH and vesicular pH during ATP depletion. Using digitized video microscopy and single, cultured rat hepatocytes, cytosolic pH and vesicular pH were quantitated by ratio imaging of BCECF (2′, 7′ biscarboxyethyl‐5, 6‐carboxyfluorescein) fluorescence and fluoresceindextran fluorescence, respectively. Basal value for cytosolic pH was 7.26 and basal value for vesicular pH was 4.86.

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