Hepatorenal reflex regulating kidney function

Florian Lang, Edda Tschernko, Eva Schulze, Irina Öttl, Markus Ritter, Harald Völkl, Christian Hallbrucker, Dieter Häussinger – 1 October 1991 – In anesthetized male rats, infusion of glutamine (2 μmol/min) into the superior mesenteric vein at a rate known to induce liver cell swelling leads to marked decreases in renal glomerular filtration rate, renal para‐aminohippurate clearance and urinary flow rate. Glutamine infused at identical rates into the jugular vein does not elicit any of these effects. The effect of glutamine is mimicked by serine but not by glutamate.

Superoxide is involved in the pathogenesis of paraquat‐induced injury in cultured rat liver slices

Hitoshi Togashi, Haruhide Shinzawa, Hiroto Wakabayashi, Toichiro Nakamura, Huang Yong, Nobuo Yamada, Katsuaki Ukai, Yoshimi Okuyama, Tsuneo Takahashi, Makoto Ishikawa – 1 October 1991 – We examined whether superoxide is a factor responsible for paraquat‐induced liver injury in terms of superoxide dismutase using cultured rat liver slices exposed to various concentrations of paraquat. The degree of liver injury was assessed by measurement of percentage of lactate dehydrogenase leakage into the medium and lipid hydroperoxides in the liver slices and by direct histopathological observation.

Subscribe to