Hepatocyte growth factor receptor and the c‐Met oncogene

Nelson Fausto – 1 October 1991 – Hepatocyte growth factor (HGF) is a plasminogen‐like protein thought to be a humoral mediator of liver regeneration. A 145‐kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the β subunit of the c‐met proto‐oncogene product, a membrane‐spanning tyrosine kinase. Covalent cross‐linking of 125I‐labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c‐met directly established the c‐met product as the cell‐surface receptor for HGF.

Hepatitis C: Improving the diagnostic armamentarium

Jorge J. Gumucio, Paul Martin – 1 October 1991 – A new four‐antigen recombinant immunoblot assay (4‐RIBA) for confirmation of hepatitis C virus (HCV) C‐100 enzyme‐linked immunosorbent assay (ELISA) reactivity was tested in stored serum samples (1984–86) of blood donors and recipients and compared with results from polymerase chain reaction (PCR) analysis of fresh (1990) plasma samples in donors and recipients from the original study.

The effect of GABA on serum and hepatic polyamine concentrations after partial hepatectomy in rats

Gerald Y. Minuk, Tony Gauthier, Aziz Gaharie, Liam J. Murphy – 1 October 1991 – Serum and hepatic polyamine concentrations including putrescine, spermidine and spermine were documented at various time intervals after partial hepatectomy in rats treated with GABA (500 μg/gm body wt) or isotonic saline. Aside from a transient decrease in spermidine levels, GABA treatment had no effect on serum polyamine concentrations.

Hepatic activity and mRNA expression of aspartate aminotransferase isoenzymes in alcoholic and nonalcoholic liver disease

Stanislas Pol, Bertrand Nalpas, Anne Vassault, Bernadette Bousquet‐Lemercier, Dominique Franco, Bernard Lacour, Pierre Berthelot, Jacques Hanoune, Robert Barouki – 1 October 1991 – In liver and serum, AST activity is dependent on two isoenzymes, which are mitochondrial and cytosolic in nature.

Hepatorenal reflex regulating kidney function

Florian Lang, Edda Tschernko, Eva Schulze, Irina Öttl, Markus Ritter, Harald Völkl, Christian Hallbrucker, Dieter Häussinger – 1 October 1991 – In anesthetized male rats, infusion of glutamine (2 μmol/min) into the superior mesenteric vein at a rate known to induce liver cell swelling leads to marked decreases in renal glomerular filtration rate, renal para‐aminohippurate clearance and urinary flow rate. Glutamine infused at identical rates into the jugular vein does not elicit any of these effects. The effect of glutamine is mimicked by serine but not by glutamate.

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