António José Lanca, Yedy Israel – 1 November 1991 – Most histochemical methods for the detection of an enzymatic activity are preceded by tissue fixation with chemical agents that partially inactivate the enzymes. It is well known that substrates exert a marked protection against fixative‐induced inactivation.
Ross A. McKinnon, Pauline de la M. Hall, Linda C. Quattrochi, Robert H. Tukey, Michael E. McManus – 1 November 1991 – To better characterize the precise cellular distribution of CYP1A gene products in man, we have undertaken Northern‐blot and in situ hybridization analyses of CYP1A expression in human liver. Using riboprobes transcribed from both CYP1A1 and CYP1A2 complementary DNAs to probe a series of Northern blots of 23 human liver messenger RNA samples, CYP1A1 expression was demonstrated in 11 samples and CYP1A2 expression was evident in 22 samples.
Shuichi Seki, Hiroki Sakaguchi, Nobuyoshi Kawakita, Atsushi Yanai, Tetsuo Kuroki, Yasuhiro Mizoguchi, Kenzo Kobayashi, Takeyuki Monna – 1 November 1991 – Proliferating cells in liver specimens from patients with various diseases were detected by use of a monoclonal antibody against human DNA polymerase‐α, which is present in the nuclei of cells in the G1, S, M and G2 phases of the mitotic cell cycle and absent in the G0 phase, to clarify the kinetics and morphological characteristics of these cells.
Steven H. Quarfordt, Eliana Defaria, Barry A. Landis, R. Randal Bollinger, Yasuo Yamaguchi – 1 November 1991 – Without a liver the fractional plasma removal of free fatty acid is one third and chylomicron triglyceride one half of that in the intact rat. The intestine of the anhepatic rat converted enteral fatty acid to plasma triglyceride but was unable to do the same for plasma free fatty acid.
Martina Sterneck, Russell Wiesner, Nancy Ascher, John Roberts, Linda Ferrell, Jurgen Ludwig, John Lake – 1 November 1991 – We report the first two cases of apparent azathioprine hepatotoxicity occurring after liver transplantation. The two patients exhibited jaundice, elevated serum transaminase activities and histopathological features of sinusoidal congestion and centrilobular hepatocellular degeneration 17 and 61 days after transplantation. After withdrawal of azathioprine, liver test results improved immediately in both patients.
Christopher P. Day, Rumaisa Bashir, Oliver F. W. James, Margaret F. Bassendine, David W. Crabb, Holly R. Thomasson, Ting‐Kai Li, Howard J. Edenberg – 1 November 1991 – Little is known about factors determining individual susceptibility to the physical complications of alcohol abuse but genetically determined differences in ethanol metabolism may be important. The oxidative metabolism of alcohol is catalyzed by alcohol and aldehyde dehydrogenase.
1 November 1991
1 October 1991
Jack R. Wands, Hubert E. Blum – 1 October 1991
Antonio Francavilla, Thomas E. Starzl, Ken Porter, Carlo Scotti Foglieni, George K. Michalopoulos, Giuseppe Carrieri, Jose Trejo, Alessandro Azzarone, Michele Barone, Qi Hua Zeng – 1 October 1991 – Completely diverting portacaval shunt (Eck's fistula) in dogs causes hepatocyte atrophy, disruption of hepatocyte organelles, fatty infiltration and lowgrade hyperplasia. The effect of hepatic growth regulatory substances on these changes was assessed by constantly infusing test substances for four postoperative days after Eck's fistula into the detached left portal vein above the shunt.