Jean‐Yves Scoazec, Gérard Feldmann – 1 November 1991 – Hepatic sinusoids are highly specialized capillary vessels characterized by the presence of resident macrophages adhering to the endothelial lining. Although it is likely that sinusoidal endothelial cells have specific adaptations, little is known about the roles that they actually play in vivo.
Luisa Benvegnù, Daniela Cavalletto, Maria Grazia Ruvoletto, Alfredo Alberti – 1 November 1991
Douglas M. Heuman, W. Michael Pandak, Philip B. Hylemon, Z. Reno Vlahcevic – 1 November 1991 – Intraduodenal infusion of hydrophobic bile salts to bile‐fistula rats leads within hours to severe hepatocellular necrosis and cholestasis; simultaneous administration of conjugates of ursodeoxycholate, either intraduodenally or intravenously, reduces or prevents liver injury.
Jorge J. Gumucio, Laurence M. Blendis – 1 November 1991 – We investigated the role of early portal hypotensive pharmacotherapy in preventing the development of portal‐systemic shunting in a portal hypertensive model of chronic murine schistosomiasis induced by infecting C3H mice with 60 cercariae of Schistosoma mansoni. Propranolol was administered in drinking water to 20 animals for a period of 6 wk at a dose of 10 mg · kg−1 d−1, starting at 5 wk of schistosomal infection. 32 age‐matched mice with chronic schistosomal infection served as controls.
António José Lanca, Yedy Israel – 1 November 1991 – Most histochemical methods for the detection of an enzymatic activity are preceded by tissue fixation with chemical agents that partially inactivate the enzymes. It is well known that substrates exert a marked protection against fixative‐induced inactivation.
Ross A. McKinnon, Pauline de la M. Hall, Linda C. Quattrochi, Robert H. Tukey, Michael E. McManus – 1 November 1991 – To better characterize the precise cellular distribution of CYP1A gene products in man, we have undertaken Northern‐blot and in situ hybridization analyses of CYP1A expression in human liver. Using riboprobes transcribed from both CYP1A1 and CYP1A2 complementary DNAs to probe a series of Northern blots of 23 human liver messenger RNA samples, CYP1A1 expression was demonstrated in 11 samples and CYP1A2 expression was evident in 22 samples.
Shuichi Seki, Hiroki Sakaguchi, Nobuyoshi Kawakita, Atsushi Yanai, Tetsuo Kuroki, Yasuhiro Mizoguchi, Kenzo Kobayashi, Takeyuki Monna – 1 November 1991 – Proliferating cells in liver specimens from patients with various diseases were detected by use of a monoclonal antibody against human DNA polymerase‐α, which is present in the nuclei of cells in the G1, S, M and G2 phases of the mitotic cell cycle and absent in the G0 phase, to clarify the kinetics and morphological characteristics of these cells.
Steven H. Quarfordt, Eliana Defaria, Barry A. Landis, R. Randal Bollinger, Yasuo Yamaguchi – 1 November 1991 – Without a liver the fractional plasma removal of free fatty acid is one third and chylomicron triglyceride one half of that in the intact rat. The intestine of the anhepatic rat converted enteral fatty acid to plasma triglyceride but was unable to do the same for plasma free fatty acid.