Superoxide is involved in the pathogenesis of paraquat‐induced injury in cultured rat liver slices
Hitoshi Togashi, Haruhide Shinzawa, Hiroto Wakabayashi, Toichiro Nakamura, Huang Yong, Nobuo Yamada, Katsuaki Ukai, Yoshimi Okuyama, Tsuneo Takahashi, Makoto Ishikawa – 1 October 1991 – We examined whether superoxide is a factor responsible for paraquat‐induced liver injury in terms of superoxide dismutase using cultured rat liver slices exposed to various concentrations of paraquat. The degree of liver injury was assessed by measurement of percentage of lactate dehydrogenase leakage into the medium and lipid hydroperoxides in the liver slices and by direct histopathological observation.