Hepatic activity and mRNA expression of aspartate aminotransferase isoenzymes in alcoholic and nonalcoholic liver disease

Stanislas Pol, Bertrand Nalpas, Anne Vassault, Bernadette Bousquet‐Lemercier, Dominique Franco, Bernard Lacour, Pierre Berthelot, Jacques Hanoune, Robert Barouki – 1 October 1991 – In liver and serum, AST activity is dependent on two isoenzymes, which are mitochondrial and cytosolic in nature.

The effect of GABA on serum and hepatic polyamine concentrations after partial hepatectomy in rats

Gerald Y. Minuk, Tony Gauthier, Aziz Gaharie, Liam J. Murphy – 1 October 1991 – Serum and hepatic polyamine concentrations including putrescine, spermidine and spermine were documented at various time intervals after partial hepatectomy in rats treated with GABA (500 μg/gm body wt) or isotonic saline. Aside from a transient decrease in spermidine levels, GABA treatment had no effect on serum polyamine concentrations.

Hepatitis C: Improving the diagnostic armamentarium

Jorge J. Gumucio, Paul Martin – 1 October 1991 – A new four‐antigen recombinant immunoblot assay (4‐RIBA) for confirmation of hepatitis C virus (HCV) C‐100 enzyme‐linked immunosorbent assay (ELISA) reactivity was tested in stored serum samples (1984–86) of blood donors and recipients and compared with results from polymerase chain reaction (PCR) analysis of fresh (1990) plasma samples in donors and recipients from the original study.

Hepatocyte growth factor receptor and the c‐Met oncogene

Nelson Fausto – 1 October 1991 – Hepatocyte growth factor (HGF) is a plasminogen‐like protein thought to be a humoral mediator of liver regeneration. A 145‐kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the β subunit of the c‐met proto‐oncogene product, a membrane‐spanning tyrosine kinase. Covalent cross‐linking of 125I‐labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c‐met directly established the c‐met product as the cell‐surface receptor for HGF.

Role of extracellular zinc and copper on metallothionein regulation in cultured rat hepatocytes

Juan Hidalgo, Allen Dingman, Justine S. Garvey – 1 October 1991 – Cellular and extracellular metallothionein contents of rat hepatocytes cultured in the presence of albumin (30 μmol/L) with zinc (1, 10, 50 and 100 μmol/L), copper (1, 10 and 50 μmol/L), zinc and copper (1, 10 and 50 μmol/L of each metal) or no metals in the culture medium have been measured by radioimmunoassay.

Transforming growth factor B and hepatic fibrosis: Cause or effect?

David A. Brenner – 1 October 1991 – Background. Cirrhosis is a diffuse process of hepatic fibrosis and regenerative nodule formation of unknown pathogenesis. Transforming growth factor (TGF) β1 induces the production of extracellular matrix proteins by liver cells and has been implicated in the pathogenesis of hepatic fibrosis in laboratory animals. TGFα is a hepatocyte mitogen that participates in liver regeneration.

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