Immunohistochemical study of extracellular matrix in acute galactosamine hepatitis in rats
A. Mieke Jonker, Freke W. J. Dijkhuis, Adriana Boes, Machiel J. Hardonk, Joris Grond – 1 March 1992 – A single injection of D‐galactosamine hydrochloride induces acute self‐limiting liver disease in rats that morphologically resembles drug‐induced hepatitis in human beings. In this immunohistochemical study we examined the localization and expression of the hepatic extracellular matrix components fibronectin, laminin, collagen type I, collagen type III and collagen type IV and of the cell surface receptors (integrins) for fibronectin and laminin.