Shinzaburo Noguchi, Yoshito Ohba, Takami Oka – 1 January 1992 – The influence of partial hepatectomy on epidermal growth factor receptor gene expression was studied in mouse liver. Epidermal growth factor receptor binding and epidermal growth factor receptor messenger RNA levels in the liver showed a rapid peak 8 hr after partial hepatectomy, whereas the sham operation had no effects on these levels. The peak epidermal growth factor receptor messenger RNA level was approximately threefold higher than preoperative values.

John J. Poterucha, Jorge Rakela, Lawrence Lumeng, Chao‐Hung Lee, Howard F. Taswell, Russell H. Wiesner – 1 January 1992 – Chronic hepatitis frequently occurs after liver transplantation. The role of hepatitis C virus infection in patients after liver transplantation is unknown, although antibodies to HCV are detected in some of these cases. The use of polymerase chain reaction techniques for the detection of hepatitis C virus RNA should improve sensitivity and specificity, particularly in these immunosuppressed patients.

Joaquim Ribeiro, Bernard Nordlinger, François Ballet, Luc Cynober, Colette Coudray‐Lucas, Marielle Baudrimont, Claire Legendre, Roland Delelo, Yves Panis – 1 January 1992 – The aim of this work was to evaluate the effect of intrasplenic hepatocellular transplantation on hepatic encephalopathy in an experimental model of chronic liver failure induced by end‐to‐side portacaval shunt in the rat.

Hideki Hagiwara, Norio Hayashi, Eiji Mita, Keiji Ueda, Tetsuo Takehara, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada – 1 January 1992 – We tested serial serum samples for hepatitis C virus RNA from patients undergoing treatment for chronic hepatitis C with interferon‐α using an assay that combined reverse transcription and polymerase chain reaction. The subjects studied were 20 patients with chronic hepatitis who had serum antibody to hepatitis C virus (anti‐C100–3).

Pierre J. A. Willemse, Lambert Ausema, Onno T. Terpstra, Eric P. Krenning, Fibo W. J. Ten Kate, Solko W. Schalm – 1 January 1992 – We studied the size of the liver graft and the host liver in six consecutive patients undergoing auxiliary heterotopic liver transplantation for chronic endstage liver disease. In all cases, a liver reduced in size by left lateral hepatectomy was inserted. The sizes of the graft and host liver were estimated by planimetry of two‐dimensional di‐isopropyl iminodiacetic acid scintigrams taken 3, 7, 21, 90 and 180 days after surgery.

Sanjeev Gupta, Jayanta Roy Chowdhury – 1 January 1992

Alain Braillon, Christophe Gaudin, Jorge L. Poo, Richard Moreau, Bertrand Debaene, Didier Lebrec – 1 January 1992 – In patients with cirrhosis, the significance of elevated plasma catecholamine concentrations is unclear. Thus we investigated the relationship between plasma catecholamine concentrations and the hemodynamic effect of pindolol (an index of sympathetic vascular tone) in 10 patients with cirrhosis.

Samuel S. Lee, Kaj Johansen, Didier Lebrec – 1 January 1992 – We studied the hemodynamics in four groups of rats with combinations of mesenteric hypertension and portal diversion. Operations created three groups with mesenteric hypertension and different degrees of portal venous diversion: mesenteric vein stenosis, portal vein stenosis and end‐to‐side portacaval anastomosis with mesenteric vein stenosis, the fourth group had only portacaval anastomosis. A control group had sham operations.

M. Sawkat Anwer, James M. Atkinson – 1 January 1992 – The effect of Ca+ + mobilizing agonists arginine vasopressin and phenylephrine on Na+/H+ exchange was studied in freshly isolated hepatocytes and isolated perfused rat livers. The activity of Na+/H+ exchange was determined from the rate of H+ efflux, 22Na uptake and pHi recovery. Arginine vasopressin and phenylephrine stimulated H+ efflux and 22Na uptake in isolated rat hepatocytes and increased the rate of pHi recovery from acid‐loaded hepatocytes. These effects were inhibited by amiloride.

Tomoaki Tomiya, Sumiko Nagoshi, Kenji Fujiwara – 1 January 1992 – Serum human hepatocyte growth factor levels were measured using a newly developed enzyme‐linked immunosorbent assay kit in patients with liver diseases. Serum human hepatocyte growth factor levels were increased in correlation with derangements of prothrombin time, total bilirubin and other parameters reflecting hepatocellular dysfunction in 112 patients with chronic liver disease. The levels were positively correlated with serum AST and ALT levels in 59 of these patients whose prothrombin times were within the normal range.