Endoscopic injection sclerotherapy for 1,000 patients with esophageal varices: A nine‐year prospective study

Makoto Hashizume, Seigo Kitano, Nobuhiro Koyanagi, Kazuo Tanoue, Masayuki Ohta, Hiroya Wada, Hirohiko Yamaga, Hidefumi Higashi, Yasunori Iso, Tetsuya Iwanaga, Keizo Sugimachi – 1 January 1992 – We report here the results of endoscopic injection sclerotherapy performed in 1,000 consecutively treated Japanese patients with esophageal varices. This prospective study covered the period from 1982 to 1990. Variceal bleeding was controlled in 215 (97.7%) of 220 patients. Esophageal varices were completely eradicated in 778 patients (77.8%); the mean number of sessions was 4.2.

Does the precore mutant of hbv cause fulminant hepatitis?

Howard C. Thomas – 1 January 1992 – Background. A nosocomial outbreak of fulminant hepatitis B occurred in five patients in Haifa, Israel. Previous investigations identified the suspected source as a carrier of hepatitis B surface antigen who was positive for antibodies to hepatitis B e antigen and had chronic liver disease. We examined the strain of hepatitis B virus (HBV) that caused this epidemic, in order to identify specific mutations in the precore or core region.

Hepatocyte growth factor/hepatopoietin A is expressed in fat‐storing cells from rat liver but not myofibroblast‐like cells derived from fat‐storing cells

Peter Schirmacher, Albert Geerts, Antonello Pietrangelo, Hans P. Dienes, Charles E. Rogler – 1 January 1992 – Hepatocyte growth factor/hepatopoietin A is a complete mitogen for parenchymal liver cells, and its expression is increased as an early response to acute liver injury. To identify the liver cell population responsible for hepatocyte growth factor gene expression, we investigated tissue sections and isolated and purified cell fractions from normal rat liver by in situ and Northern blot hybridization.

The effect of liver denervation on hepatic hemodynamics during hypovolemic shock in swine

J. Michael Henderson, Gregory J. Mackay, Alan B. Lumsden, Hussein M. Atta, Richard Brouillard, Michael H. Kutner – 1 January 1992 – This study tested the hypothesis that the denervated liver is more susceptible to hypovolemic shock than the normal liver. Fourteen swine, seven nondenervated and seven after liver denervation, were studied during hypovolemic shock to 50% of baseline blood pressure. Hepatic artery and portal vein flows were measured using transonic flow probes, and cardiac output and central venous pressure were measured using Swan‐Ganz catheters.

Colchicine clearance is impaired in alcoholic cirrhosis

Jonathan A. Leighton, Michael K. Bay, Alma L. Maldonado, Steven Schenker, K. Vincent Speeg – 1 December 1991 – Colchicine may have benefit in primary biliary cirrhosis and alcoholic liver disease. It is currently used in patients with impaired liver function, yet little is known about its elimination in such patients. Colchicine clearance in the rat is significantly impaired in various models of liver disease. To study this in human beings, colchicine pharmacokinetics were compared in normal subjects and patients with alcoholic cirrhosis.

Cell cycle–dependent uptake of putrescine and its importance in regulating cell cycle phase transition in cultured adult mouse hepatocytes

Roger L. Martin, Kenneth F. Ilett, Rodney F. Minchin – 1 December 1991 – Previous studies in which investigators have induced the rate of polyamine uptake in vitro have used either inhibitors of polyamine biosynthesis or growth factors that induce cell proliferation. Recently, however, we have described the induction of putrescine uptake in cultured adult mouse hepatocytes and have shown that uptake is independent of both intracellular polyamine levels and proliferation.

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