Fukashi Doi, Tomomochi Goya, Motomichi Torisu – 1 June 1993 – We investigated the pathogenesis of septic liver injury in rats caused by cecal ligation and puncture. In this model, numerous neutrophils accumulated in the liver in parallel with the development of liver dysfunction. The supernatants of hepatic macrophages isolated from these septic rats 24 hr after cecal ligation and puncture had enhanced chemotactic activities for human neutrophils. These results suggest that in sepsis, hepatic macrophages attract neutrophils to the liver.

Daniel Shouval, Ruth Adler, Yaron Ilan – 1 June 1993 – Recipients of allogeneic bone marrow transplantation are immunosuppressed as a result of their primary disease and by myeloablative therapy. Such patients are dependent on multiple blood products and are at risk for hepatitis B virus infection. Active immunization against hepatitis B in the immediate pre‐ and post‐transplant periods is ineffective, pre‐ sumably because of decreased T cell–dependent B‐cell responses.

Maria A. Leo, Alan S. Rosman, Charles S. Lieber – 1 June 1993 – Carotenoids and tocopherols are major natural protective agents against free radical–mediated liver damage, but their levels in diseased liver are largely uncharted. Therefore we carried out measurements with high‐pressure liquid chromatography of α‐ and β‐carotene, lycopene, cryptoxanthin, lutein and zeaxanthin, total retinoids and α‐ and γ‐tocopherol. Liver tissue was obtained from percutaneous needle biopsies, livers of transplant recipients or a donor bank.

John B. Watkins – 1 June 1993

Kunio Suzuki, Norio Hayashi, Yutaka Sasaki, Michikazu Kono, Akinori Kasahara, Yutaka Imai, Hideyuki Fusamoto, Takenobu Kamada – 1 June 1993 – To evaluate structural changes in diffuse liver disease, frequency domain analysis was applied to ultrasonic signals from the liver. We assumed that liver tissue is a collection of semiregularly arrayed small scatterers of ultrasound. We applied cepstral analysis to the ultrasonic waveforms and evaluated the periodicity of scalloping of the power spectrum caused by an interference effect among liver scatterers of a given spacing.

Daniel Azoulay, Antoinette Lemoine, Ashley Dennison, Jean Michel Gries, Isabelle Dolizy, Denis Castaing, Philippe Beaune, Henri Bismuth – 1 June 1993 – Despite the availability of whole‐blood cyclosporine assays, the different responses of individual patients to its administration after transplantation continue to pose clinical problems, particularly with respect to toxicity. Fifty‐seven recipients of first orthotopic liver transplants were studied between January 1992 and July 1992.

Thomas E. Starzl, Anthony J. Demetris, Massimo Trucco, Noriko Murase, Camillo Ricordi, Suzanne Ildstad, Hector Ramos, Satoru Todo, Andreas Tzakis, John J. Fung, Michael Nalesnik, Adriana Zeevi, William A. Rudert, Mirjana Kocova – 1 June 1993

1 June 1993

Nobukazu Yuki, Norio Hayashi, Hideki Hagiwara, Tetsuo Takehara, Kazuhiro Katayama, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada – 1 June 1993 – We quantified IgG antibodies to structural (core) and nonstructural (C100‐3) hepatitis C virus proteins in 42 patients with chronic hepatitis C treated with a 6‐mo course of interferon‐α Sera were drawn before and at the end of therapy and also 6 mo after therapy withdrawal; they were stored for later analysis of antibodies and serum hepatitis C virus RNA.

Emilio Rocchi, Marco Cassanelli, Athos Borghi, Franco Paolillo, Marcello Pradelli, Giovanna Casalgrandi, Aldo Burani, Ennio Gallo – 1 June 1993 – The need for accurate and noninvasive evaluation of liver iron stores prompted us to evaluate the reliability of high‐field magnetic resonance imaging equipment in liver patients with low or moderate siderosis, given the poor results obtained using systems operating at low field strength in such cases.