Lactitol or lactulose in the treatment of chronic hepatic encephalopathy: Results of a meta‐analysis

Pierre Blanc, Jean‐Pierre Daures, Jean‐Michel Rouillon, Pascale Peray, Robert Pierrugues, Dominique Larrey, François Gremy, Henri Michel – 1 February 1992 – Lactitol (β‐galactosido‐sorbitol) has been recently compared with lactulose for the treatment of chronic hepatic encephalopathy in a few studies, each comprising a small number of patients. The results are controversial. We studied the efficiency and tolerance of both compounds by using a meta‐analysis on the basis of published controlled trials.

Portal‐vein obstruction in children leads to growth retardation

Shiv K. Sarin, Anupam Bansal, Shailja Sasan, Aruna Nigam – 1 February 1992 – The portal vein is the main source of blood and hepatotrophic factors to the liver. Partial portal‐vein ligation in rats results in reduced growth compared with that in control rats. To investigate whether extrahepatic portal vein obstruction occurring in early childhood influences growth in humans, anthropometric and nutritional assessments were prospectively carried out in 61 patients with extrahepatic portal vein obstruction.

Fibroproliferation in liver disease: Role of monocyte factors

Theresa C. Peterson, Richard A. Isbrucker – 1 February 1992 – Fibroproliferation was measured as the uptake of [3H]thymidine into fibroblasts. Human fibroblasts were incubated with 200 μl monocyte‐conditioned medium, the 0.22 μm filtrate from cultured monocytes, in Dulbecco's modified Eagle medium supplemented with controlled process serum replacement 2, a fetal calf serum substitute with low mitogenic activity. Increasing the numbers of fibroblasts resulted in a parallel increase in thymidine uptake to a maximal level.

Oral bile acid treatment and the patient with zellweger syndrome

Kenneth D. R. Setchell, Patrizia Bragetti, Linda Zimmer‐Nechemias, Cynthia Daugherty, Maria Antonietta Pelli, Renato Vaccaro, Giorgio Gentili, Eleonora Distrutti, Giuliano Dozzini, Antonio Morelli, Carlo Clerici – 1 February 1992 – The cerebrohepatorenal syndrome of Zellweger is a congenital syndrome of multiple manifestations, including hepatomegaly and liver dysfunction. Treatment is generally of a supportive nature, aimed at improving nutrition and growth, controlling the central nervous system symptoms and limiting progression of liver disease.

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