Garwin K. Sing, Raymond Pace, Sharon Prior, Janet S. D. Scott, Paul Shield, Nicole Martin, Jeffrey Searle, Cameron Battersby, Lawrie W. Powell, W. Graham E. Cooksley – 1 July 1994 – We describe the establishment and characterization of a novel hepatoma cell line. This cell line, designated RBHF‐1, was established from a hepatocellular carcinoma of a 67‐yr‐old man with a history of genetic hemochromatosis. At this writing, the cells have been maintained in RPMI‐1640 tissue‐culture medium and fetal calf serum without any additional supplements for 30 mo.

1 July 1994

Jean‐Pierre Benhamou – 1 July 1994

Marcel Blaise, Dominique Pateron, Jean‐Claude Trinchet, Serge Levacher, Michel Beaugrand, Jean‐Louis Pourriat – 1 July 1994 – This randomized prospective study was aimed at assessing the efficiency of a systemic antibiotic therapy for the prevention of bacterial infections in cirrhotic patients with gastrointestinal hemorrhage by ruptured esophageal varices. For 15 mo, all patients hospitalized with no infection on admission, were included in the study. Starting on admission day, patients in group A received ofloxacin (400 mg/day) for 10 days, first intravenously then orally.

Federico G. Villamil – 1 July 1994 – Background. The role of liver transplantation in patients positive for the hepatitis B surface antigen (HBsAg) is controversial because of the high rate of recurrent hepatitis B virus (HBV) infection. It has not been determined whether this risk is greater for certain patients and whether the administration of anti‐hepatitis B surface antigen (anti‐HBe) immune globulin is beneficial.

Roger Williams, Julia Wendon – 1 July 1994 – The decision to undertake transplantation in a patient with fulminant liver failure requires consideration of many factors so that the physician may arrive at the most appropriate course of action. There are several definitions of fulminant liver failure used in current practice, all excluding patients with chronic liver disease. In the one most recently proposed, the terms hyperacute, acute and subacute liver failure are used to categorize groups of patients with different clinical appearances and progress.

Ruud A. F. Krom – 1 July 1994 – Medical selection criteria should be the same for all patients with end‐stage liver disease and should aim for an acceptable outcome of the liver transplant procedure in matter of survival and quality of life, taking the scarce resources into account. The psychiatric selection criteria should aim at avoidance of recidivism of alcohol use in alcoholic patients. At least 6 mo of sobriety should be required. The patient must have a stable and supportive environment and should participate in an alcohol counseling program.

Gianluigi Giannelli, Paola Savoia, Oronzo Schiraldi, Mario Lospalluti, Michele De Luca, Pier Carlo Marchisio, Vito Quaranta – 1 July 1994 – Psoriatic lesions are relatively frequent in patients with chronic liver disease. Furthermore, therapy with interferons tends to exacerbate the symptoms. The pathogenesis of psoriatic lesions is unclear. An important question is whether such lesions may be linked to the underlying chronic liver disease in these patients, or whether they are incidental manifestations of psoriasis vulgaris.

Shuichiro Okamoto, Kazuhisa Fukushima, Hidetaka Higashijima, Ichiro Makino, Masanori Kishinaka, Hitoshi Oda, Hiroyuki Yamashita, Hitoshi Ichimiya, Kazuo Chijiiwa, Syoji Kuroki – 1 July 1994 – To examine the hypothesis that serum levels of 7α‐hydroxycholesterol reflect bile acid synthesis in the liver, we analyzed serum 7α‐hydroxycholesterol and bile acid output in 13 patients with obstructive jaundice after relief of biliary obstruction.

Gianluca Svegliati‐Baroni, Enrique Baraona, Alan S. Rosman, Charles S. Lieber – 1 July 1994 – Alcoholic and, to a lesser extent, nonalcoholic patients with liver disease have serum antibodies to acetaldehyde‐protein adducts produced in vitro. These antibodies presumably reflect the presence of adducts in the liver, but the protein that triggers this immune response has not been identified.