Seroprevalence of hepatitis C virus nucleocapsid antibodies in patients with cryptogenic chronic liver disease

Jonathan Brown, Spyros Dourakis, Peter Karayiannis, Robert Goldin, Joe Chiba, Hiroyoshi Ohba, Tatsuo Miyamura, Howard C. Thomas – 1 February 1992 – The serological responses to two different hepatitis C virus antigens were studied by enzyme‐linked immunosorbent assay in a variety of chronic liver diseases and in healthy blood donors.

Temporal relationship of peripheral vasodilatation, plasma volume expansion and the hyperdynamic circulatory state in portal‐hypertensive rats

Luis A. Colombato, Agustin Albillos, Roberto J. Groszmann – 1 February 1992 – Peripheral vasodilatation and plasma volume expansion are required to generate the hyperdynamic circulatory state observed in portal hypertension.

Changes in transcripts of basement components during rat liver development: Increase in laminin messenger RNAs in the neonatal period

Shimon Reif, Donald Sykes, Thomas Rossi, Milton M. Weiser – 1 February 1992 – The expression of laminin and type IV collagen messenger RNA in rat liver was investigated in relation to liver development. Levels of messenger RNA for laminin chains A, B1 and B2, and α1 and α2 chains of type IV collagen were studied by Northern‐blot and dot‐blot analysis. Although the expression of messenger RNAs for laminin B1 and B2 chains was higher in 19‐day gestational fetal liver when compared with the adult, the highest level was detected in 15‐day newborns.

Oral bile acid treatment and the patient with zellweger syndrome

Kenneth D. R. Setchell, Patrizia Bragetti, Linda Zimmer‐Nechemias, Cynthia Daugherty, Maria Antonietta Pelli, Renato Vaccaro, Giorgio Gentili, Eleonora Distrutti, Giuliano Dozzini, Antonio Morelli, Carlo Clerici – 1 February 1992 – The cerebrohepatorenal syndrome of Zellweger is a congenital syndrome of multiple manifestations, including hepatomegaly and liver dysfunction. Treatment is generally of a supportive nature, aimed at improving nutrition and growth, controlling the central nervous system symptoms and limiting progression of liver disease.

Fibroproliferation in liver disease: Role of monocyte factors

Theresa C. Peterson, Richard A. Isbrucker – 1 February 1992 – Fibroproliferation was measured as the uptake of [3H]thymidine into fibroblasts. Human fibroblasts were incubated with 200 μl monocyte‐conditioned medium, the 0.22 μm filtrate from cultured monocytes, in Dulbecco's modified Eagle medium supplemented with controlled process serum replacement 2, a fetal calf serum substitute with low mitogenic activity. Increasing the numbers of fibroblasts resulted in a parallel increase in thymidine uptake to a maximal level.

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