Margaret Swain, Roger F. Butterworth, Andres T. Blei – 1 March 1992 – The pathogenesis of brain edema in acute liver failure is poorly understood. We have previously shown that rats with ischemic acute liver failure (portacaval anastomosis followed by hepatic artery ligation) exhibit brain edema and intracranial hypertension, with swelling of cortical astrocytes as the most prominent neuropathological abnormality.

Raymond S. Koff – 1 March 1992

Tetsuo Takehara, Norio Hayashi, Eiji Mita, Hideki Hagiwara, Keiji Ueda, Kazuhiro Katayama, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada – 1 March 1992 – The combination of reverse transcription and polymerase chain reaction is a very powerful tool for the detection of hepatitis C virus RNA in sera of patients with hepatitis C virus infection. However, when studying the presence of this virus in tissue using polymerase chain reaction, it may be difficult to distinguish between blood viral particles adhering to the tissue and viral RNA contained within the tissue.

Patrick S. C. Leung, Takashi Iwayama, Thomas Prindiville, David T. Chuang, Aftab A. Ansari, R. Max Wynn, Rollie Dickson, Ross Coppel, M. Eric Gershwin – 1 March 1992 – The appearance of autoantibodies against mitochondria in patients with primary biliary cirrhosis has been known for more than 25 yr. In the past, based on the biochemical complexity of the mitochondrion and the use of crude extracts for immunodiagnosis, a degree of nonspecificity in assaying for antibodies to mitochondria has been present.

Andrew E. Mulberg, Richard J. Grand – 1 March 1992

Defeng Wu, Arthur I. Cederbaum – 1 March 1992 – Recent experiments have described the presence of cytochrome P‐450 and certain P‐450 isozymes in the plasma membrane of rat liver. Experiments were carried out to evaluate whether cytochrome P‐450IIE1 was present in the plasma membrane fraction of livers from control rats and rats treated with 4‐methylpyrazole, which induces this isozyme.

Erica Baker, Des Richardson, Sharon Gross, Prem Ponka – 1 March 1992 – A range of new analogues of the promising iron chelator pyridoxal isonicotinoyl hydrazone was prepared and assessed for activity in reducing hepatocyte iron, mechanism of action and potential in iron‐chelation therapy.

Tai‐Wing Wu, Zdenek B. Pristupa, Ling‐Hua Zeng, Jian‐Xun Au, Jun Wu, Hiroshi Sugiyama, Doug Carey – 1 March 1992 – When Trolox (a polar analog of vitamin E) is conjugated to p‐aminophenyl‐β‐D‐lactopyranoside, the resulting lactosylphenyl Trolox becomes a markedly more stable and effective hepatoprotector than Trolox. In primary rat hepatocytes exposed to xanthine oxidase–hypoxanthine, lactosylphenyl Trolox prolonged cell survival better than did Trolox, mannitol or ascorbate.

Mordechai Rabinovitz, Judith S. Gavaler, Robert H. Kelly, Martin Prieto, David H. Van Thiel – 1 March 1992 – Homozygous α1‐antitrypsin deficiency (PiZZ phenotype) is known to be associated with increased risk of cirrhosis and primary liver cancer. Although a relationship between heterozygous α1‐antitrypsin deficiency and chronic liver disease was suggested recently, it is still a matter of controversy whether such patients are at increased risk of liver cancer.

Elisabeth Paietta, Richard J. Stockert, Janis Racevskis – 1 March 1992 – The human hepatic asialoglycoprotein receptor comprises two homologous polypeptides designated H1 and H2. Two distinct complementary DNA clones encoding these receptor subunits have been previously isolated from the human hepatoblastoma cell line HepG2. We discovered that multiple variants of H2 transcripts exist both in HepG2 cells and in the normal human liver that, at least in part, appear to be the result of alternative splicing events.