Hypercholesterolemia and atherosclerosis in primary biliary cirrhosis: What is the risk?

Jeffrey S. Crippin, Kieth D. Lindor, Roberta Jorgensen, Bruce A. Kottke, Jay M. Harrison, Paul A. Murtaugh, E. Rolland Dickson – 1 May 1992 – Hypercholesterolemia is commonly associated with primary biliary cirrhosis. In the general population, elevated serum cholesterol is associated with an increased risk of atherosclerosis. The relative risk has been poorly defined in primary biliary cirrhosis patients with hyperlipidemia. In addition, the hyperlipidemic state seen with primary biliary cirrhosis has not been well studied.

Effects of rapamycin on cultured hepatocyte proliferation and gene expression

Antonio Francavilla, Brian I. Carr, Thomas E. Starzl, Alessandro Azzarone, Giuseppe Carrieri, Qui‐Hua Zeng – 1 May 1992 – Rapamycin, a potent immunosuppressive drug that disrupts normal signal‐transduction processes, inhibited hepatocyte proliferation without evidence of inherent cytotoxicity in rat hepatocytes cultured in conventional medium or in a medium enriched with epidermal growth factor. The antiproliferative effect was dose dependent, uninfluenced by the concentration of epidermal growth factor in the medium and long lasting after a brief exposure.

Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody—treated liver transplant patients

Gerald McMahon, Paul H. Ehrlich, Zeinab A. Moustafa, Linda A. McCarthy, Diane Dottavio, Mark D. Tolpin, Paul I. Nadler, Lars Östberg – 1 May 1992 – A gene region encoding a segment of the major surface protein, HBsAg, of hepatitis B virus was analyzed from serum samples after orthotopic liver transplantation of three hepatitis B virus chronic carrier patients treated with a human anti—hepatitis B virus monoclonal antibody (SDZ OST 577).

Renal effects in cirrhotic patients with avid sodium retention of atrial natriuretic factor injection during norepinephrine infusion

Salvatore Badalamenti, Gianmario Borroni, Elettra Lorenzano, Pierluigi Incerti, Francesco Salerno – 1 May 1992 – The administration of atrial natriuretic factor to patients with cirrhosis, and avid sodium retention causes marked hypotension and blunted kidney responses.

Changes in bilirubin pigments secreted in bile after liver transplantation

Carl A. Goresky, Ellen R. Gordon, Juan‐Ramon Sanabria, Steven M. Strasberg, M. Wayne Flye – 1 May 1992 – The species of bile pigments secreted in T‐tube fistula bile after liver transplantation were ascertained by high‐performance liquid chromatography in 15 patients for 10 days after liver transplant. Nine glycosidic conjugates and unconjugated bilirubin were resolved by the analytical procedure.

Mirex‐induced adaptive liver growth in rats subjected to thyroidectomy

James D. Yarbrough, Jo M. Grimley, Jaideep V. Thottassery – 1 May 1992 – The organochlorine compound mirex (dodecachlorooctahydro‐1,3,4‐metheno‐2H‐cyclobuta‐CD‐pentalene) induces an adaptive liver growth dependent on the hormonal status of the experimental animal. In the intact laboratory rat, mirex induces liver growth that is an expression of both cellular hyperplasia and hypertrophy. However, in rats subjected to adrenalectomy, mirex induces liver growth that is essentially hyperplastic.

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