Interrelationships of bile acid and phospholipid fatty acid species with cholesterol saturation of duodenal bile in health and gallstone disease

Frieder Berr, Edgar Schreiber, Ulrich Frick – 1 July 1992 – The relative amount of cholesterol and the fatty acid composition of phosphatidylcholines in bile can be influenced by the bile acid species secreted.

Direct measurement of hepatic blood flow in native and transplanted organs, with accompanying systemic hemodynamics

A. William Paulsen, Goran B. G. Klintmalm – 1 July 1992 – The purpose of this study was to investigate intraoperatively a population of patients with end‐stage liver disease before and after liver transplantation with respect to (a) the range of hepatic and systemic hemodynamics and their changes associated with transplantation and (b) the ability to identify native hemodynamic correlates with specific diagnostic groups. Hepatic artery and portal vein blood flows were determined with square‐wave electromagnetic flowmetry.

Morphological differences between hepatocellular carcinoma and hepatocellular carcinomalike lesions

Ikuko Motohashi, Masahiko Okudaira, Tomoko Takai, Satoshi Kaneko, Noriaki Ikeda – 1 July 1992 – In an attempt to provide a quantitative basis for differentiation between well‐differentiated hepatocellular carcinoma and hepatocellular carcinomalike lesions (focal nodular hyperplasia, regenerative nodular hyperplasia and hepatocellular adenoma), histopathological and morphometrical analyses were performed on 208 cases of various liver diseases with the aid of an image analyzer.

Association between heterozygous β1‐antitrypsin deficiency and genetic hemochromatosis

Mordechai Rabinovitz, Judith S. Gavaler, Robert H. Kelly, David H. Van Thiel – 1 July 1992 – Primary hemochromatosis is a genetically determined autosomal recessive disorder characterized by the excessive accumulation of body iron, most of which is deposited in the parenchymal cells of various organs.

Urea and protein synthesis in cold‐preserved isolated rat hepatocytes

Paul K. Vreugdenhil, Diane C. Marsh, Folkert O. Belzer, James H. Southard – 1 July 1992 – We used an isolated‐hepatocyte model to study how hypothermic storage (simulating liver preservation) affects metabolism after prolonged preservation. Rat hepatocytes were stored in the University of Wisconsin solution for up to 72 hr. After each day of storage, protein synthesis, urea synthesis, ATP content and lactate dehydrogenase release were determined in rewarmed (37° C) and oxygenated hepatocytes.

Provocative gene therapy strategy for the treatment of hepatocellular carcinoma

Frederick Askari, James Wilson – 1 July 1992 – An approach involving retroviral‐mediated gene therapy for the treatment of neoplastic disease is described. This therapeutic approach is called “virus‐directed enzyme/prodrug therapy” (VDEPT). The VDEPT approach exploits the transcriptional differences between normal and neoplastic cells to achieve selective killing of neoplastic cells. We now describe development of the VDEPT approach for the treatment of hepatocellular carcinoma.

Hepatitis B virus DNA in peripheral‐blood mononuclear cells in chronic hepatitis B after HBsAg clearance

Andrew Mason, Boris Yoffe, Christine Noonan, Mary Mearns, Carolyn Campbell, Amanda Kelley, Robert P. Perrillo – 1 July 1992 – In this study, peripheral‐blood mononuclear cells from patients with chronic hepatitis B and spontaneous or therapy‐induced disappearance of HBsAg were examined for HBV DNA. Samples were evaluated by in situ hybridization and polymerase chain reaction both before and after clearance of HBsAg.

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