Norman L. Sussman, Maria G. Chong, Tarek Koussayer, Da‐Er He, Thomas A. Shang, Hartwell H. Whisennand, James H. Kelly – 1 July 1992 – Liver transplantation is currently the only effective therapy for patients with fulminant hepatic failure. The availability of an artificial liver could bridge these patients through the relatively brief crisis period and allow their own livers to regenerate, providing a more favorable outcome and sparing the trauma and expense of transplant.

Jeremiah P. Donovan, Byers W. Shaw, Alan N. Langnas, Michael F. Sorrell – 1 July 1992

1 July 1992

Carlos V. Paya, Russell H. Wiesner, Paul E. Hermans, Jeffrey J. Larson‐Keller, Duane M. Ilstrup, Ruud A. F. Krom, S. Breanndon Moore, Jurgen Ludwig, Thomas F. Smith – 1 July 1992 – In this study we evaluated the association between cytomegalovirus infection alone or in relation to human leukocyte antigen matching and the development of vanishing bile duct syndrome, a form of chronic hepatic allograft rejection.

S. Dasarathy, Manisha Dwivedi, Dinesh K. Bhargava, K. R. Sundaram, K. Ramachandran – 1 July 1992 – A prospective randomized study was conducted to compare the efficacy of long‐term endoscopic sclerotherapy vs. propranolol in Child class B and C patients with variceal bleeds within the 30 days before the study. Forty‐five and 46 patients were randomized to receive sclerotherapy and propranolol, respectively, after preentry stratification for Child scores. Sclerotherapy was administered with 1% polidocanol at 10‐day intervals until obliteration of varices was achieved.

Solange Bresson‐Hadni, Jean‐Philippe Miguet, Daniele Lenys, Dominique‐Angele Vuitton, Gabriel Viennet, Marie‐Claude Becker, Paul Rohmer, Georges Mantion, Michel Gillet – 1 July 1992

Jean‐Michel Pawlotsky, Chantal Andre, Jean‐Michel Metreau, Michel Beaugrand, Elie‐Serge Zafrani, Daniel Dhumeaux – 1 July 1992 – Multiple nuclear dots antinuclear antibodies display a specific immunofluorescence pattern on HEp‐2 cells. They have been reported to be strongly associated with primary biliary cirrhosis, especially when sicca syndrome was present.

Oscar L. Lopez, Conrado Estol, Immaculada Colina, Jorge Quiroga, Oscar C. Imvertarza, David H. Van Thiel – 1 July 1992 – Postoperative neurological complications in 185 patients who underwent two or more orthotopic liver transplantations were reviewed. The most common neurological complications were alteration of mental status (84%), seizures (33%) and focal motor deficits (15%). The frequency of neurological complications after a second orthotopic liver transplantation was significantly greater than that after a single orthotopic liver transplantation.

Carl A. Goresky, K. Sandy Pang, Andreas J. Schwab, Ford Barker Iii, Wendy F. Cherry, Glen G. Bach – 1 July 1992 – The hepatocytic entry of acetaminophen sulfate conjugate was examined in the rat liver, perfused with red cells with and without albumin, by use of the multiple‐indicator dilution technique.

Jae‐Hag Lee, Teresa G. Paglieroni, Paul V. Holland, Jerome B. Zeldis – 1 July 1992 – Viral sequence and host immune response were investigated in an unusual, asymptomatic chronic hepatitis B virus carrier (human leukocyte antigen type A24, Bw61, Bw62, Bw6, DRw11, DRw52, DQw7) who was consistently nonreactive for antibody to HBc and had a normal ALT level over a 5‐yr study period. The precore and core region DNA sequences of virus isolated from his serum had seven silent mutations that resulted in no changes in the amino acid sequence of the adr HBsAg subtype.