Effects of rapamycin on cultured hepatocyte proliferation and gene expression
Antonio Francavilla, Brian I. Carr, Thomas E. Starzl, Alessandro Azzarone, Giuseppe Carrieri, Qui‐Hua Zeng – 1 May 1992 – Rapamycin, a potent immunosuppressive drug that disrupts normal signal‐transduction processes, inhibited hepatocyte proliferation without evidence of inherent cytotoxicity in rat hepatocytes cultured in conventional medium or in a medium enriched with epidermal growth factor. The antiproliferative effect was dose dependent, uninfluenced by the concentration of epidermal growth factor in the medium and long lasting after a brief exposure.