John C. Deutsch, Mieko M. Iwahashi, Eileen M. Sutherland, John Mapoles, Francis R. Simon – 1 May 1992 – The uptake of tri‐hydroxy conjugated bile salts by hepatocytes is principally by a sodium‐dependent carrier. We examined the uptake kinetics of the high‐specific‐activity, hydroxylated, conjugated bile salt 125I‐labeled cholyl‐glycyl‐tyrosine, to determine whether this synthetic bile salt was transported by the sodium‐dependent bile salt system. 125I‐labeled cholyl‐glycyl‐tyrosine was synthesized, and its transport kinetics were studied in freshly cultured rat hepatocytes.

1 May 1992

Etienne M Sokal, Joelle Mostin, Jean Paul Buts – 1 May 1992 – Liver cell functional heterogeneity has been shown to persist in toxic CCl4 cirrhosis in growing rats, but the zonation observed in cirrhotic nodules may be different in other types of cirrhosis. To investigate this possibility, we looked at the zonal activities of two microsomal enzymes, glucose‐6‐phosphatase and NADPH dehydrogenase, in cirrhotic nodules from growing rats with chronic cholestasis. Zonal activities were measured by quantitative cytochemistry and microdensitometry.

Kensaku Hata, David H. van Thiel, Ronald B. Herberman, Theresa L. Whiteside – 1 May 1992 – Liver‐derived lymphocytes were isolated from 73 liver biopsy specimens obtained from patients with chronic active liver disease and from six samples of normal liver. Mean absolute numbers (±S.E.M) of liver‐derived lymphocytes recovered from needle biopsy specimens by mild enzymatic digestion of the liver tissue varied from 0.7 ± 0.3 × 10/mm in allografts being rejected to 8.9 ± 0.9 × 10/mm in chronic non‐A, non‐B hepatitis.

Lluis Viladomiu, Joan Genescà, Juan I. Esteban, Helena Allende, Antonio González, Juan Carlos López‐Talavera, Rafael Esteban, Jaime Guardia – 1 May 1992 – To assess the efficacy of interferon‐α in acute hepatitis C, 28 patients with acute posttransfusion hepatitis were randomized to receive 3 million units of recombinant interferon‐α three times weekly for 12 wk or no treatment. Biochemical, histological and serological parameters were monitored during 1 yr of follow‐up.

K. Vincent Speeg, Alma L. Maldonado, Julie Liaci, Donna Muirhead – 1 May 1992 – The multidrug resistance transport protein is a normal constituent of the liver canalicular membrane, although its function has not been defined in vivo. Colchicine, a multidrug resistance substrate, is eliminated mainly by the liver. Cyclosporine reverses multidrug resistance in vitro, presumably by inhibiting the multidrug resistance transporter. This study assesses biliary colchicine elimination and the effect of cyclosporine on this process.

Russell H. Wiesner – 1 May 1992 – Background. In primary biliary cirrhosis the hepatic lesions may result, at least in part, from the intracellular accumulation of potentially toxic endogenous bile acids. Preliminary work suggests that the administration of ursodiol (also called ursodeoxycholic acid), a hydrophilic bile acid without hepatotoxicity, leads to improvement in the condition of patients with primary biliary cirrhosis.

Abraham P. Bautista, John J. Spitzer – 1 May 1992 – This study examines the generation of superoxide anion by the perfused rat liver after ethanol intoxication and acute endotoxemia to assess the potential importance of oxygen‐derived free radicals in the ethanol‐induced hepatic pathological condition. Hepatic superoxide anion production of 0.65 ± 0.06 nmol/min/gm liver weight was measured 1 hr after ethanol infusion; it reached a peak value of 0.8 ± 0.07 at 3 hr and was reduced to 0.11 ± 0.01 by 7 hr.

Hong‐Yuan Hsu, Mei‐Hwei Chang, Kue‐Hsiung Hsieh, Chin‐Yun Lee, Ho‐Hsiung Lin, Lih‐Hwa Hwang, Pei‐Jer Chen, Ding‐Shinn Chen – 1 May 1992 – Cellular immunity to HBcAg was studied in hepatitis B virus carrier children and neonates born to hepatitis B virus carrier mothers. A significant proliferative response of peripheral blood mononuclear cells to HBcAg was found in 5 of 10 children with elevated ALT levels but in none of the nine HBeAg‐positive children with normal ALT levels.

Paul Martin – 1 May 1992 – Objective: To determine the epidemiologic, clinical, serologic, and histologic importance of antibodies to hepatitis C virus (anti‐HCV) in blood donors.