Effect of simvastatin, ursodeoxycholic acid and simvastatin plus ursodeoxycholic acid on biliary lipid secretion and cholic acid kinetics in nonfamilial hypercholesterolemia

Giuseppe Mazzella, Paolo Parini, Davide Festi, Franco Bazzoli, Rita Aldini, Aldo Roda, Domenica Tonelli, Antonio Cipolla, Antonio Salzetta, Enrico Roda – 1 June 1992 – It has been recently shown that the newest hypocholesterolemic agent, simvastatin, lowers the biliary cholesterol saturation index and that its association with ursodeoxycholic acid renders it more effective.

Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure

Masataka Kato, Robin D. Hughes, Richard T. Keays, Roger Williams – 1 June 1992 – Cerebral edema is a serious complication of the encephalopathy in fulminant hepatic failure. It is a major cause of death. The mechanisms responsible for its formation are unclear, and the aim of this study was to investigate the ultrastructural appearance of brain capillaries by scanning electron microscopy.

Extracellular matrix regulation of hepatic transcription factors is dependent on cell structure

Erin G. Schuetz – 1 June 1992 – The extracellular matrix (ECM) promotes tissue morphogenesis, cell migration, and the differentiation of a variety of cell types. However, the mechanisms by which ECM causes differentiated gene expression have been unknown. In this report, we show that culturing the hepatocyte‐derived cell line H2.35 on an ECM gel changes cell morphology and selectively stimulates the transcription of a subset of liver‐specific genes, including serum albumin.

The touch that hepatocytes seem to like

Kenneth S. Zaret – 1 June 1992 – We have identified the liver‐regulating protein (LRP), a cell surface protein involved in the maintenance of hepatocyte differentiation when cocultured with rat liver epithelial cells (RLEC). LRP was defined by immunoreactivity to a monoclonal antibody (mAb L8) prepared from RLEC. mAb L8 specifically detected two polypeptides of 85 and 73 kD in immunoprecipitation of both hepatocyte‐ and RLEC‐iodinated plasma membranes.

Stereological and functional analysis of liver mitochondria from rats with secondary biliary cirrhosis: Impaired mitochondrial metabolism and increased mitochondrial content per hepatocyte

Stefan Krähenbühl, Sonja Krähenbühl‐Glauser, Jörg Stucki, Peter Gehr, Jürg Reichen – 1 June 1992 – Mitochondrial and cytosolic functions were studied in vivo and in perfused livers from rats with secondary biliary cirrhosis induced by bile duct ligation for 5 wk and in sham‐operated controls. The livers were stereo‐logically analyzed, and mitochondrial and cytosolic functions were related to liver structure. Oxygen consumption by perfused livers expressed per stereo‐logically determined mitochondrial volume was decreased by 49% in bile duct—ligated rats compared with control rats.

Hepatic allograft cyclosporine concentration is independent of the route of cyclosporine administration and correlates with the occurrence of early cellular rejection

William J. Sandborn, George M. Lawson, Ruud A. F. Krom, Russell H. Wiesner – 1 June 1992 – This study compares the hepatic‐tissue cyclosporine concentrations in liver biopsy specimens from patients with and without cellular rejection after orthotopic liver transplantation. Nine patients without cellular rejection were studied, including five patients receiving intravenous cyclosporine who had biopsies on posttransplant day 7 and four patients receiving oral cyclosporine who had biopsies on day 21.

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