Cholesterol nucleation time in gallbladder bile of patients with solitary or multiple cholesterol gallstones

Dieter Jüngst, Thomas Lang, Christoph von Ritter, Ekkehard Pratschke, Gustav Paumgartner – 1 May 1992 – Patients with multiple cholesterol gallbladder stones have been found to be at a higher risk for the recurrence of gallstones after successful nonsurgical treatment than those with a solitary stone. Cholesterol gallstone recurrence, like primary gallstone formation, probably involves a triple defect with supersaturation, abnormally rapid nucleation of cholesterol in bile and altered gallbladder motor function.

Sequence of exons and the flanking regions of human bilirubin‐UDP‐glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler‐Najjar syndrome, type I

Piter J. Bosma, Namita Roy Chowdhury, Bart G. Goldhoorn, Martin H. Hofker, Ronald P. J. Oude Elferink, Peter L. M. Jansen, Jayanta Roy Chowdhury – 1 May 1992 – Crigler‐Najjar syndrome, type I is a heterogeneous disorder that may result from mutations of various regions of the bilirubin‐UDP‐glucuronosyltransferase gene complex that encodes two bilirubin‐UDP‐glucuronosyltransferase isoforms and a phenol‐UDP‐glucuronosyltransferase isoform in the human liver.

Mirex‐induced adaptive liver growth in rats subjected to thyroidectomy

James D. Yarbrough, Jo M. Grimley, Jaideep V. Thottassery – 1 May 1992 – The organochlorine compound mirex (dodecachlorooctahydro‐1,3,4‐metheno‐2H‐cyclobuta‐CD‐pentalene) induces an adaptive liver growth dependent on the hormonal status of the experimental animal. In the intact laboratory rat, mirex induces liver growth that is an expression of both cellular hyperplasia and hypertrophy. However, in rats subjected to adrenalectomy, mirex induces liver growth that is essentially hyperplastic.

Changes in bilirubin pigments secreted in bile after liver transplantation

Carl A. Goresky, Ellen R. Gordon, Juan‐Ramon Sanabria, Steven M. Strasberg, M. Wayne Flye – 1 May 1992 – The species of bile pigments secreted in T‐tube fistula bile after liver transplantation were ascertained by high‐performance liquid chromatography in 15 patients for 10 days after liver transplant. Nine glycosidic conjugates and unconjugated bilirubin were resolved by the analytical procedure.

Renal effects in cirrhotic patients with avid sodium retention of atrial natriuretic factor injection during norepinephrine infusion

Salvatore Badalamenti, Gianmario Borroni, Elettra Lorenzano, Pierluigi Incerti, Francesco Salerno – 1 May 1992 – The administration of atrial natriuretic factor to patients with cirrhosis, and avid sodium retention causes marked hypotension and blunted kidney responses.

Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody—treated liver transplant patients

Gerald McMahon, Paul H. Ehrlich, Zeinab A. Moustafa, Linda A. McCarthy, Diane Dottavio, Mark D. Tolpin, Paul I. Nadler, Lars Östberg – 1 May 1992 – A gene region encoding a segment of the major surface protein, HBsAg, of hepatitis B virus was analyzed from serum samples after orthotopic liver transplantation of three hepatitis B virus chronic carrier patients treated with a human anti—hepatitis B virus monoclonal antibody (SDZ OST 577).

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