Endotoxins inhibit endocytotic catabolism of low‐density lipoproteins in Hep G2 cells
Wei Liao, Claes‐Henrik Florén – 1 July 1992 – The effects of endotoxins on the uptake and degradation of low‐density lipoproteins in Hep G2, a welldifferentiated human hepatoma cell line, were studied. The results showed that incubation of Hep G2 cells with125I‐labeled low‐density lipoprotein in the presence of endotoxins caused decreased uptake and degradation of125I‐labeled low‐density lipoprotein. The inhibitory effects of endotoxins on the uptake and degradation of125I‐labeled low‐density lipoprotein were dose and time dependent.